Evidence map›Paper›PMID 37084727›Full record

ArticleStem cell reports2023

IRX5 promotes DNA damage repair and activation of hair follicle stem cells.

Jefferson K Chen, Julie Wiedemann, Ly Nguyen, Zhongqi Lin, Mahum Tahir, Chi-Chung Hui, Maksim V Plikus, Bogi Andersen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jefferson K ChenDepartments of Biological Chemistry and Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Julie WiedemannDepartments of Biological Chemistry and Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA, USA; Mathematical, Computational and Systems Biology (MCSB) Program, University of California, Irvine, Irvine, CA, USA.
Ly NguyenDepartments of Biological Chemistry and Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Zhongqi LinDepartments of Biological Chemistry and Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Mahum TahirDepartments of Biological Chemistry and Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Chi-Chung HuiProgram in Developmental & Stem Cell Biology, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Maksim V PlikusDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Bogi AndersenDepartments of Biological Chemistry and Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA, USA. Electronic address: bogi@uci.edu.
University of California, Irvine · USUniversity of Toronto · CA

Funding

Transcriptional Co-Regulators in EpidermisR01AR044882 · NIAMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI Bogi Andersen · 1998 to 2026
$9.0M
Control of hair follicle cyclingR01AR056439 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen · 2010 to 2026
$5.4M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2019 to 2025
$5.1M
Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
IRX in epidermal differentiationF30HD093392 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, JEFFERSON · 2017 to 2021
$215k
NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R01 AR044882NIAMS NIH HHS R01 AR056439NIAMS NIH HHS U01 AR073159NICHD NIH HHS F30 HD093392NIGMS NIH HHS T32 GM136624
6 · The paper itself

Abstract

The molecular mechanisms allowing hair follicles to periodically activate their stem cells (HFSCs) are incompletely characterized. Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5

Indexed as

Hair FollicleStem CellsAnimalsDNA DamageGene Expression RegulationHomeodomain ProteinsMiceSignal TransductionTranscription FactorsHomeodomain ProteinsIrx5 protein, mouseTranscription FactorsBRCA1cancercell cycleDNA damageFGF18hair cyclehair follicle stem cellsinterfollicular epidermal stem cellsIrx5stem cell activation

Identifiers

PMID37084727
PMCPMC10202659
OpenAlexW4366520880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.