Evidence map›Paper›PMID 37084634›Full record

ArticleJournal of molecular and cellular cardiology2023

OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.

Rebeca Rodriguez, Michael Harris, Elizabeth Murphy, Leslie M Kennedy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebeca RodriguezCardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
Michael HarrisCardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
Elizabeth MurphyCardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
Leslie M KennedyCardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America. Electronic address: Leslie.Kennedy@nih.gov.
National Heart Lung and Blood Institute · US

Funding

Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZ01HL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2008 to 2008
$607k
Intramural NIH HHS Z01 HL002066Intramural NIH HHS ZIA HL002066
6 · The paper itself

Abstract

Cardiac hypertrophy is associated with increased translation. However, little is known of the mechanisms that regulate translation in hypertrophy. Members of the 2-oxoglutarate-dependent dioxygenase family regulate several aspects of gene expression, including translation. An important member of this family is OGFOD1. Here, we show OGFOD1 accumulates in failing human hearts. Upon OGFOD1 deletion, murine hearts showed transcriptomic and proteomic changes, with only 21 proteins and mRNAs (0.6%) changing in the same direction. Additionally, OGFOD1-KO mice were protected from induced hypertrophy, supporting a role for OGFOD1 in the cardiac response to chronic stress.

Indexed as

Nuclear ProteinsProteomicsAnimalsCardiomegalyCarrier ProteinsHeartHumansIsoproterenolMiceMyocytes, CardiacProcollagen-Proline DioxygenaseCarrier ProteinsIsoproterenolNuclear ProteinsOGFOD1 protein, humanOgfod1 protein, mouseProcollagen-Proline Dioxygenaseproline, 2-oxoglutarate 3-dioxygenaseCardiac hypertrophyHeart failurePost-translational modificationsProline hydroxylationTranslation

Identifiers

PMID37084634
PMCPMC10862384
OpenAlexW4366363653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.