ArticleDrug and alcohol dependence2023
Neuroaffective reactivity profiles are associated with vulnerability to e-cigarette use.
Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 7 citations in OpenAlex.
- Personalizing smoking cessation pharmacotherapy using neuroaffective reactivity profiles: A randomized controlled trial.Addiction (Abingdon, England) · 2026Trial
- Attentional bias toward emotional and cigarette cues: Insights from a computer mouse-tracking task in adults who smoke and adults who do not smoke.Drug and alcohol dependence · 2026Article
- Article
- Dissociating moral identity from neural markers of the late positive potential in emotional attention to smoking and non-smoking stimuli.AIMS neuroscience · 2026Article
- Profiles of Neuroaffective Responding to Natural Reward-Predicting Cues and Alcohol Images in Alcohol Use Disorder: An Event-Related Potential Approach.bioRxiv : the preprint server for biology · 2025Article
- Clustering computer mouse tracking data with informed hierarchical shrinkage partition priors.Biometrics · 2024Article
- Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study.Addiction neuroscience · 2024Article
- Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder.Journal of psychiatric research · 2024Article
- Individual differences in late positive potential amplitude and theta power predict cue-induced eating.Addiction neuroscience · 2023Article
- Towards neuromarkers for tailored smoking cessation treatments.Addiction neuroscience · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe tested whether neuroaffective responses to motivationally salient stimuli are associated with vulnerability to cue-induced e-cigarette use in e-cigarette naïve adults who smoke daily. We hypothesized that individuals with stronger neuroaffective responses to nicotine-related cues than to pleasant stimuli (the C>P reactivity profile) would be more vulnerable to cue-induced nicotine self-administration than individuals with stronger neuroaffective responses to pleasant stimuli than to nicotine-related cues (the P>C reactivity profile).
methodsWe used event-related potentials (ERPs, a direct measure of cortical activity) to measure neuroaffective reactivity to pleasant, unpleasant, neutral, and nicotine-related cues indicating the opportunity to use an e-cigarette in 36 participants. For each picture category, we computed the amplitude of the late positive potential (LPP), a robust index of motivational salience. To identify each individual's neuroaffective reactivity profile we applied k-means cluster analysis on the LPP responses. We compared the e-cigarette use frequency across profiles using quantile regression for counts.
resultsK-means cluster analysis assigned 18 participants to the C>P profile and 18 participants to the P>C profile. Individuals with the C>P neuroaffective profile used the e-cigarette significantly more often than those with the P>C profile. Significant differences in the number of puffs persisted across different quantiles.
conclusionsThese results support the hypothesis that individual differences in the tendency to attribute motivational salience to drug-related cues underlie vulnerability to cue-induced drug self-administration. Targeting the neuroaffective profiles that we identified with tailored treatments could improve clinical outcomes.
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