Evidence map›Paper›PMID 37084160›Full record

ArticleAdvances in therapy2023

Association Between Percutaneous Oxygen Saturation and Mortality of Patients with Mild Traumatic Brain Injury at ICU Admission: An Analysis of the MIMIC-III Database.

Wei Sun, Ling Wang, Shiqi Yuan, Rongrong Liu, Pingping Song, Wenqiang Che, Jiamin Xu, Jun Lyu, Yusheng Zhang

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Article in Advances in therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Wei SunDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Ling WangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Shiqi YuanDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Rongrong LiuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Pingping SongDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Wenqiang CheDepartment of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jiamin XuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jun LyuDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China. lyujun2020@jnu.edu.cn.
Yusheng ZhangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou, China. jneuro@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResearch related to the result of patients with mild traumatic brain injury and the role of percutaneous oxygen saturation (SpO2) level is rarely reported. Our study investigated the relationship between SpO2 and the 30- and 90-day mortality among patients with mild TBI.

methodsA total of 1027 patients with mild TBI [Glasgow Coma Scale (GCS) > 12] were enrolled from the Medical Information Mart for Intensive Care (MIMIC-III) database. The patients were classified into low-SpO2 (< 95%), moderate-SpO2 (95-98%), and high-SpO2 groups (> 98%). With 30- and 90-day mortality rates as the main outcomes, Cox regression and confined cubic spline models were adopted.

resultsThere was a U-shaped curve in confined cubic splines for the relationship between SpO2 and mortality. Compared with the moderate-SpO2 group, the high-SpO2 group exhibited a much higher risk of mortality after modification, with hazard proportions of 2.108 (95% CI 1.211-3.670, P < 0.05) for the 30-day mortality and 1.760 (95% CI 1.140-2.720, P < 0.05) for the 90-day mortality, and the low-SpO2 group exhibited a much higher risk of mortality after modification, with hazard proportions of 2.215 (95% CI 1.194-4.110, P < 0.05) for the 90-day mortality.

conclusionAmong patients with mild TBI, the correlation between SpO2 level and 30- and 90-day mortality followed a U-shaped curve. Both low and high SpO2 level exerted potential harmful effects on the outcomes of patients with mild TBI. The SpO2 range of 95-98% could be the optimal SpO2 level for mild patients with TBI.

Indexed as

Brain ConcussionGlasgow Coma ScaleHospitalizationHumansIntensive Care UnitsOxygen SaturationBrain injuryHyperoxiaHypoxiaMortalityOxygen therapyPercutaneous oxygen saturation

Identifiers

PMID37084160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.