Evidence map›Paper›PMID 37083742›Full record

ArticleEuropean radiology2023

Evaluation of the impact of a novel denoising algorithm on image quality in dual-energy abdominal CT of obese patients.

Fides R Schwartz, Darin P Clark, Francesca Rigiroli, Kevin Kalisz, Benjamin Wildman-Tobriner, Sarah Thomas, Joshua Wilson, Cristian T Badea, Daniele Marin

Abstract read
In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fides R SchwartzDepartment of Radiology, Duke University Health System, 2301 Erwin Road, Box 3808, Durham, NC, 27110, USA. fides.schwartz@duke.edu.
Darin P ClarkQuantitative Imaging and Analysis Lab, Department of Radiology, Duke University, Durham, NC, USA.
Francesca RigiroliDepartment of Radiology, Duke University Health System, 2301 Erwin Road, Box 3808, Durham, NC, 27110, USA.
Kevin KaliszDepartment of Radiology, Duke University Health System, 2301 Erwin Road, Box 3808, Durham, NC, 27110, USA.
Benjamin Wildman-TobrinerDepartment of Radiology, Duke University Health System, 2301 Erwin Road, Box 3808, Durham, NC, 27110, USA.
Sarah ThomasDepartment of Radiology, Duke University Health System, 2301 Erwin Road, Box 3808, Durham, NC, 27110, USA.
Joshua WilsonClinical Imaging Physics Group, Durham, NC, USA.ORCID http://orcid.org/0000-0002-4175-6301
Cristian T BadeaQuantitative Imaging and Analysis Lab, Department of Radiology, Duke University, Durham, NC, USA.
Daniele MarinDepartment of Radiology, Duke University Health System, 2301 Erwin Road, Box 3808, Durham, NC, 27110, USA.

Funding

The Duke Preclinical Research Resources for Quantitative Imaging BiomarkersU24CA220245 · NCI · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2017 to 2021
$2.8M
Development of a New Generation Micro-CT imaging for Functional and Molecular Imaging of CancerR01CA196667 · NCI · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2015 to 2019
$2.3M
Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart diseaseRF1AG070149 · NIA · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2021 to 2022
$2.1M
Multiorgan Photon Counting CT and Machine Learning to Elucidate Aging Mechanisms and InterventionsR01AG070149 · NIA · DUKE UNIVERSITY · PI CRISTIAN T BADEA, Alexandra Badea · 2024 to 2026
$2.1M
NCI NIH HHS R01 CA196667NCI NIH HHS U24 CA220245NIA NIH HHS R01 AG070149NIA NIH HHS RF1 AG070149NIH HHS R01 CA196667NIH HHS U24 CA 220245
6 · The paper itself

Abstract

objectivesEvaluate a novel algorithm for noise reduction in obese patients using dual-source dual-energy (DE) CT imaging.

methodsSeventy-nine patients with contrast-enhanced abdominal imaging (54 women; age: 58 ± 14 years; BMI: 39 ± 5 kg/m

resultsAverage CNR was 5.0 ± 1.9 (original), 31.1 ± 10.3 (comparison; p < 0.001), and 8.9 ± 2.9 (test; p < 0.001). Readers were in good to moderate agreement over perceived image noise (ICC: 0.83), image quality (ICC: 0.71), and diagnostic comfort (ICC: 0.6). Diagnostic accuracy was low across algorithms (accuracy: 66, 63, and 67% (original, comparison, test)). The noise received a mean score of 54, 84, and 66 (p < 0.05); image quality 59, 61, and 65; and the diagnostic comfort 63, 68, and 68, respectively. Quality and comfort scores were not statistically significantly different between algorithms.

conclusionsThe test algorithm produces quantitatively higher image quality than current standard and existing denoising algorithms in obese patients imaged with DECT and readers show a preference for it. CLINICAL RELEVANCE STATEMENT: Accurate diagnosis on CT imaging of obese patients is challenging and denoising algorithms can increase the diagnostic comfort and quantitative image quality. This could lead to better clinical reads. KEY POINTS: • Improving image quality in DECT imaging of obese patients is important for accurate and confident clinical reads, which may be aided by novel denoising algorithms using image domain data. • Accurate diagnosis on CT imaging of obese patients is especially challenging and denoising algorithms can increase quantitative and qualitative image quality. • Image domain algorithms can generalize well and can be implemented at other institutions.

Indexed as

AlgorithmsTomography, X-Ray ComputedAdultAgedFemaleHumansMiddle AgedObesityPhantoms, ImagingRadiation DosageRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesSignal-To-Noise RatioImage quality enhancementMedical image processingMultidetector computed tomographyObesityTomography, X-ray computed

Identifiers

PMID37083742
PMCPMC10902821

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.