Evidence map›Paper›PMID 37083696›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2023

Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction.

Scott A Greilach, Laura L McIntyre, Quy H Nguyen, Jorge Silva, Kai Kessenbrock, Thomas E Lane, Craig M Walsh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Scott A GreilachDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA.
Laura L McIntyreDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA.
Quy H NguyenDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA.
Jorge SilvaDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA.
Kai KessenbrockDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA.
Thomas E LaneDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA.
Craig M WalshDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA.
University of California, Irvine · US

Funding

Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER01AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2020
$2.5M
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER56AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2016
$103k
NIAID NIH HHS R01 AI121945NIAID NIH HHS R56 AI121945NINDS NIH HHS T32 NS082174
6 · The paper itself

Abstract

Transplantation of human neural stem cells (hNSCs) is a promising regenerative therapy to promote remyelination in patients with multiple sclerosis (MS). Transplantation of hNSCs has been shown to increase the number of CD4+CD25+Foxp3+ T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong localized remyelination response. However, the mechanisms by which hNSC transplantation leads to an increase in Tregs in the CNS remains unclear. We report that hNSCs drive the conversion of T conventional (Tconv) cells into Tregs in vitro. Conversion of Tconv cells is Ag driven and fails to occur in the absence of TCR stimulation by cognate antigenic self-peptides. Furthermore, CNS Ags are sufficient to drive this conversion in the absence of hNSCs in vitro and in vivo. Importantly, only Ags presented in the thymus during T cell selection drive this Treg response. In this study, we investigate the mechanisms by which hNSC Ags drive the conversion of Tconv cells into Tregs and may provide key insight needed for the development of MS therapies.

Indexed as

Multiple SclerosisNeural Stem CellsAnimalsCD4 AntigensCD4-Positive T-LymphocytesForkhead Transcription FactorsHumansLymphocyte ActivationMiceT-Lymphocytes, RegulatoryCD4 AntigensForkhead Transcription Factors

Identifiers

PMID37083696
PMCPMC10192095
OpenAlexW4366603663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.