ArticlePloS one2023
Risk of cancer in patients with insomnia: Nationwide retrospective cohort study (2009-2018).
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Associations between sleep traits and colorectal cancer: a mendelian randomization analysis.Frontiers in oncology · 2025Pooled it
- The association between sleep quantity, insomnia and lung cancer risk - A systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Sleep duration, selected circulating biomarkers, and colorectal cancer risk.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Electroencephalogram-guided anesthesia and postoperative anxiety and depression in elderly gastric cancer patients with sleep disorders.World journal of psychiatry · 2026Article
- Investigating the causal relationship between insomnia and ovarian cancer risk: a Mendelian randomization study.Discover oncology · 2025Article
- Insomnia Symptoms, Mental Health Diagnosis, Mental Health Care Utilization, and Perceived Barriers in U.S. Males and Females.Journal of clinical medicine · 2025Article
- Sleep factors and risk of thyroid cancer, nodules and dysfunction: Mendelian randomization study.Gland surgery · 2025Article
- Insomnia in relation to 10 urological and reproductive conditions: a two-sample Mendelian randomization study.Translational andrology and urology · 2025Article
- Sleep health: an unappreciated key player in colorectal cancer.Journal of Cancer · 2025Review
- Causal relationship between insomnia and thyroid disease: A bidirectional Mendelian randomization study.Brain and behavior · 2024Article
- Association between sleep traits and risk of colorectal cancer: a bidirectional Mendelian randomization study.Journal of gastrointestinal oncology · 2024Article
- Metabolic underpinnings of cancer-related fatigue.American journal of physiology. Endocrinology and metabolism · 2024Review
- The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study.Cancers · 2023Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association between insomnia and the risk of various cancers using the Korean National Health Insurance Service database. MATERIALS AND
methodsPatients who underwent a national health examination in 2009 were followed-up until 2018. Newly-diagnosed cancers were collected one year after the baseline. Insomnia was defined as having a diagnosis of F510 or G470 within one year prior to enrollment. The incidence of various cancers was compared between patients with and without insomnia.
resultsIn the overall study population (N = 3,982,012), the risk for any type of cancer was not different between controls and insomnia patients (adjusted hazard ratio [aHR]: 0.990). However, it was different by age; insomnia increased the risk of any cancer in younger age groups (20-39y and 40-59y, aHR:1.310 and 1.139, respectively) but it significantly decreased the risk in the 60-79y age group (aHR: 0.939). In cancer type, colorectal cancer risk was lower (aHR: 0.872, P < 0.0001), whereas leukemia risk was higher (aHR: 1.402, P < 0.0001) in patients with insomnia than in those without it, regardless of sex. In men, the risk of stomach cancer was lower (aHR: 0.882, P = 0.0003), and the risks of lung (aHR:1.114, P = 0.0005), kidney (aHR 1.226, P = 0.0107), and prostate (aHR:1.101, P = 0.0028) cancers were higher in insomnia patients than in control patients. In women, insomnia patients compared to control patients showed a lower risk of ovarian cancer (aHR:0.856, P = 0.0344, respectively), while they had a higher risk of oral (aHR:1.616, P = 0.002), thyroid (aHR:1.072, P = 0.0192), and nerve (aHR: 1.251, P = 0.016) cancers.
conclusionInsomnia is associated with an increased or decreased risk of some cancers, depending on age, cancer type and sex.
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