Evidence map›Paper›PMID 37083555›Full record

ArticleeLife2023

Single-cell transcriptomics of a dynamic cell behavior in murine airways.

Sheldon J J Kwok, Daniel T Montoro, Adam L Haber, Seok-Hyun Yun, Vladimir Vinarsky

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Profiling Dynamic Patterns of Single-Cell Motility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sheldon J J Kwok *Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, United States.
Daniel T Montoro *Broad Institute of MIT and Harvard, Cambridge, United States.ORCID 0000-0002-6222-2149
Adam L Haber *Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States.ORCID 0000-0002-4229-2852
Seok-Hyun YunHarvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, United States.ORCID 0000-0002-8176-9916
Vladimir VinarskyCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, United States.ORCID 0000-0003-1141-6434

Funding

Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
Laser particles for multi-dimensional single-cell analysisR01EB033155 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2021 to 2025
$3.5M
Re-establishment of directional mucociliary transport after epithelial injuryK08HL124298 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VINARSKY, VLADIMIR · 2014 to 2018
$796k
Cellular crosstalk in the maintenance of lung epithelial homeostasisF32HL154638 · NHLBI · BROAD INSTITUTE, INC. · PI MONTORO, DANIEL THOMAS · 2020 to 2022
$133k
NHLBI NIH HHS F32 HL154638NHLBI NIH HHS K08 HL124298NHLBI NIH HHS P01 HL120839NIBIB NIH HHS R01 EB033155
6 · The paper itself

Abstract

Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways.

Indexed as

Gene Expression ProfilingTranscriptomeAnimalsMiceSingle-Cell Analysisairwaysdevelopmental biologymigrationmouseregenerative medicinestem cellstwo-photon imaging

Identifiers

PMID37083555
PMCPMC10174686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.