Evidence map›Paper›PMID 37083535›Full record

ArticleScience advances2023

Delivering a toxic metal to the active site of urease.

Yap Shing Nim, Ivan Yu Hang Fong, Justin Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi and 3 more

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Molecular structure and nickel-binding capacity of Proteus mirabilis UreE.Acta crystallographica. Section D, Structural biology · 2026
    Article
  3. Article
  4. New Directions inInfection and drug resistance · 2025
    Review
  5. Component characterization ofFrontiers in cellular and infection microbiology · 2025
    Article
  6. Review
  7. Article
  8. [Mechanisms ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Review
  9. Sumner's legacy: a century of urease crystals and recent structural advances.Critical reviews in biochemistry and molecular biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yap Shing NimSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0001-9259-6603
Ivan Yu Hang FongSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Justin DemeSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.ORCID 0000-0001-8811-9871
Ka Lung TsangSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.
Joseph CaesarSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Steven JohnsonSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Longson Tsz Hin PangSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0003-0709-9835
Nicholas Man Hon YuenSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-4761-9930
Tin Long Chris NgSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0003-4779-7646
Tung ChoiSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0009-0007-6316-7990
Yakie Yat Hei WongSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0009-0003-2564-2974
Susan M LeaSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.ORCID 0000-0001-9287-8053
Kam-Bo WongSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-6984-5373

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Medical Research Council MR/S021264/1NIGMS NIH HHS R01 GM129325Wellcome Trust
6 · The paper itself

Abstract

Urease is a nickel (Ni) enzyme that is essential for the colonization of

Indexed as

Helicobacter pyloriUreaseBacterial ProteinsCatalytic DomainCryoelectron MicroscopyHumansKlebsiellaNickelBacterial ProteinsNickelUrease

Identifiers

PMID37083535
PMCPMC10121161

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.