Evidence map›Paper›PMID 37083466›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

The

Buyan-Ochir Orgil, Undral Munkhsaikhan, Joseph F Pierre, Ning Li, Fuyi Xu, Neely R Alberson, Jason N Johnson, Glenn T Wetzel, Bastiaan J D Boukens, Lu Lu and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Expression Levels of theInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Buyan-Ochir OrgilDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0001-7932-2237
Undral MunkhsaikhanDepartment of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-7241-9172
Joseph F PierreDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-4248-1290
Ning LiDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-1642-2393
Fuyi XuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Neely R AlbersonDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Jason N JohnsonDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Glenn T WetzelDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Bastiaan J D BoukensDepartment of Medical Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Jeffrey A TowbinDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Enkhsaikhan PurevjavDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0001-6188-7176
University of Tennessee Health Science Center · USAmsterdam UMC Location University of Amsterdam · NLBinzhou Medical University · CNHarbin Medical University · CNSt. Jude Children's Research Hospital · USUniversity of Wisconsin–Madison · US

Funding

PEDIATRIC CARDIOMYOPATHY REGISTRYR01HL053392 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 1995 to 2009
$8.3M
Pediatric Cardiomyopathy Specimen RepositoryR01HL087000 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TOWBIN, JEFFREY ALLEN · 2007 to 2010
$2.2M
Genetic Modulation of Hypertrophic Cardiomyopathy SeverityR01HL128350 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, SUN, YAO · 2016 to 2019
$2.0M
NHLBI NIH HHS R01 HL053392NHLBI NIH HHS R01 HL087000NHLBI NIH HHS R01 HL128350
6 · The paper itself

Abstract

The transmembrane protein 43 (TMEM43/LUMA) p.S358L mutation causes arrhythmogenic cardiomyopathy named as ARVC5, a fully penetrant disease with high risk of ventricular arrhythmias, sudden death, and heart failure. Male gender and vigorous exercise independently predicted deleterious outcome. Our systems genetics analysis revealed the importance of

Indexed as

Arrhythmogenic Right Ventricular Dysplasiabeta CateninAnimalsArrhythmias, CardiacHomeostasisIntestine, SmallMaleMembrane ProteinsMiceMutationMyocytes, CardiacPPAR gammabeta CateninMembrane ProteinsPPAR gammaTmem43 protein, mousearrhythmogenic cardiomyopathyARVC5PPARGTMEM43/LUMAWnt-β-catenin

Identifiers

PMID37083466
PMCPMC10190833
OpenAlexW4366603486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.