ArticleScience immunology2023
Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- A systematic review of molecular signaling in the muscle-brain-gut axis: exercise-induced myokines and microbial metabolites as key mediators.Molecular biology reports · 2026Pooled it
- Targeting tissue immune memory in chronic-remitting autoimmune kidney diseases: current concepts and future therapies.Clinical kidney journal · 2026Review
- Single-cell RNA sequencing reveals clonally expanded CD4+ tissue-resident memory T cells in histidyl-tRNA synthetase-induced myositis.JCI insight · 2026Article
- CD8MedComm · 2026Review
- Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Tissue-resident memory T cells in organ transplantation: implications for immune homeostasis and graft outcomes.Inflammation and regeneration · 2026Review
- Best practices in mouse models of skin transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- BHLHE40 Orchestrates Effector Tissue-Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy.Results and problems in cell differentiation · 2026Review
- IL-1β-induced STAT3 activation drives IL-17-producing CD8Journal of translational medicine · 2025Article
- Review
- Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025Review
- Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors.Cell reports. Medicine · 2025Article
- Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Allergic Contact Dermatitis: Immunopathology and Potential Therapeutic Strategies.Journal of clinical medicine · 2025Review
- Review
- Immunosenescence: signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Roger TieuMedical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0001-9339-5096
Qiang ZengNationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-2372-3466
Daqiang ZhaoThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0003-2582-0112
Gang ZhangThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Neda FeiziThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Priyanka ManandharDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-2868-5286
Amanda L WilliamsDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Benjamin PoppThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Michelle A Wood-TrageserThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1880-4926
Anthony J DemetrisThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-9582-3733
J Yun TsoJN Biosciences, Mountain View, CA 94043, USA.
Aaron J JohnsonDepartments of Immunology, Neurology, and Molecular Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.ORCID 0000-0002-7921-484X
Lawrence P KaneDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5198-516X
Khodor I Abou-DayaDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8788-2728
Warren D ShlomchikDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-0430-9078
Martin H OberbarnscheidtDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-2040-809X
Fadi G LakkisDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-9937-2637
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · USJN Biosciences (United States) · USMayo Clinic · USNationwide Children's Hospital · US
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MTRAINING PROGRAM FOR MD/PHD STUDENTST32GM008208 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINMAN, RICHARD A · 1987 to 2021
$15.4MT Cell Memory in Organ TransplantationR01AI049466 · NIAID · YALE UNIVERSITY · PI LAKKIS, FADI G. · 2001 to 2024
$7.5MCD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · NINDS · MAYO CLINIC ROCHESTER · PI Aaron J Johnson · 2017 to 2026
$4.6MInterdisciplinary Training in Transplantation BiologyT32AI074490 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Angus W Thomson · 2007 to 2026
$4.2MGraft-versus-Host Disease: Local Maintenance in Target Tissues by Tissue Resident Memory-Type Cells.R01HL143349 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Warren D Shlomchik · 2018 to 2026
$4.0MTertiary Lymphoid Organs in TransplantationR01AI145881 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OBERBARNSCHEIDT, MARTIN H · 2019 to 2023
$1.9MRegulation of PI3K by PIK3IP1/TrIPR01GM136148 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KANE, LAWRENCE P. · 2020 to 2023
$1.3MImageStreamX MarkIIS10OD019942 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BORGHESI, LISA · 2015 to 2015
$543kSpecial BD LSRFortessaTMS10OD011925 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BORGHESI, LISA · 2012 to 2012
$383kTissue Resident Memory T Cells in Chronic Allograft NephropathyF30DK124925 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIEU, ROGER · 2020 to 2023
$183kNCI NIH HHS P30 CA015083NHLBI NIH HHS R01 HL143349NIAID NIH HHS R01 AI049466NIAID NIH HHS R01 AI145881NIAID NIH HHS T32 AI074490NIDDK NIH HHS F30 DK124925NIGMS NIH HHS R01 GM136148NIGMS NIH HHS T32 GM008208NIH HHS S10 OD011925NIH HHS S10 OD019942NINDS NIH HHS R01 NS103212
Abstract
Our understanding of tissue-resident memory T (T
Indexed as
CD8-Positive T-LymphocytesInterleukin-15AntigensB-Cell Activating FactorHumansInflammationMemory T CellsAntigensB-Cell Activating FactorInterleukin-15TNFSF13B protein, humanTnfsf13b protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.