Evidence map›Paper›PMID 37083300›Full record

Trial reportCancer medicine2023

Emotion regulation and choice of bilateral mastectomy for the treatment of unilateral breast cancer.

Jin-Xiao Zhang, Allison W Kurian, Booil Jo, Bita Nouriani, Eric Neri, James J Gross, David Spiegel

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03050463 (Impact of Affect Reactivity and Regulation on Breast Cancer Treatment Decisions), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03050463 completednot on this map

Impact of Affect Reactivity and Regulation on Breast Cancer Treatment Decisions

TypeobservationalSponsorStanford UniversityRan2016 to 2021Enrolled178ConditionsHealthy Subject, Stage 0 Breast Cancer, Stage IA Breast Cancer, Stage IB Breast CancerArmsBiospecimen Collection, Functional Magnetic Resonance Imaging, Questionnaire Administration
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jin-Xiao ZhangDepartment of Psychology, Stanford University, Stanford, California, USA.ORCID 0000-0001-8794-1505
Allison W KurianDepartments of Medicine and of Epidemiology and Population Health, Stanford University, Stanford, California, USA.
Booil JoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Bita NourianiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Eric NeriDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
James J GrossDepartment of Psychology, Stanford University, Stanford, California, USA.
David SpiegelDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Stanford University · USStanford Health Care · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Impact of Affect Reactivity and Regulation on Breast Cancer Treatment DecisionsU01CA197282 · NCI · STANFORD UNIVERSITY · PI GROSS, JAMES J, SPIEGEL, DAVID · 2015 to 2019
$3.1M
NCATS NIH HHS UL1 TR003142NCI NIH HHS U01 CA197282
6 · The paper itself

Abstract

backgroundThere has been steadily increasing use of bilateral mastectomy (BMX) in the treatment of primary breast cancer (BC). In this study, we utilized functional magnetic resonance imaging (fMRI) to examine the influence of emotion regulation on the decision of newly diagnosed BC patients to choose BMX rather than non-BMX treatments.

methodsWe recruited 123 women with unilateral BC, 61 of whom received BMX and 62 of whom received non-BMX treatments, and 39 healthy controls. While participants were in the fMRI scanner, we showed them BC-related and non-BC-negative images. In one condition, they were instructed to watch the images naturally. In another, they were instructed to regulate their negative emotion. We compared the fMRI signal during these conditions throughout the brain.

resultsWith non-BC-negative images as the baseline, BC patients showed greater self-reported reactivity and neural reactivity to BC-related images in brain regions associated with self-reflection than did controls. Among the BC patients, the BMX group showed weaker activation in prefrontal emotion regulation brain regions during emotion regulation than did the non-BMX group.

conclusionsBC patients are understandably emotionally hyper-reactive to BC-related stimuli and those who ultimately received BMX experience more difficulty in regulating BC-related negative emotion than non-BMX BC patients. These findings offer neuropsychological evidence that difficulty in managing anxiety related to the possibility of cancer recurrence is a factor in surgical treatment decision-making and may be an intervention target with the goal of strengthening the management of cancer-related anxiety by nonsurgical means.

trial registrationNCT03050463.

Indexed as

Breast NeoplasmsEmotional RegulationUnilateral Breast NeoplasmsEmotionsFemaleHumansMagnetic Resonance ImagingMastectomyNeoplasm Recurrence, Localbilateral mastectomybreast canceremotion regulationfMRIprefrontal

Identifiers

PMID37083300
PMCPMC10278496
OpenAlexW4366602174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.