Evidence map›Paper›PMID 37083049›Full record

ArticleInnate immunity2023

A TLR4 agonist liposome formulation effectively stimulates innate immunity and enhances protection from bacterial infection.

Jodi F Hedges, Deann T Snyder, Amanda Robison, Macy A Thompson, Klara Aspelin, Jack Plewa, Jory Baldridge, Mark A Jutila

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Liposomal Delivery ofPharmaceutics · 2026
    Article
  2. Frontiers in cellular and infection microbiology · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jodi F HedgesDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.ORCID 0000-0002-7461-3972
Deann T SnyderDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.
Amanda RobisonDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.
Macy A ThompsonDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.
Klara AspelinDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.
Jack PlewaDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.
Jory BaldridgeTotem BioSciences, 240 Old Corvallis Road, Hamilton, MT 59840, USA.
Mark A JutilaDepartment of Microbiology and Cell Biology, Montana State University, P.O. Box 173610, Bozeman, MT, USA.
Montana State University · USPacific Biosciences (United States) · US

Funding

Optimized phage therapy for Brucella infectionR21AI144496 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI JUTILA, MARK A · 2019 to 2020
$360k
NIAID NIH HHS R21 AI144496
6 · The paper itself

Abstract

Stimulation of innate immunity can protect against infectious insult and could be used in combination with other therapies. Since antibiotic resistance is an increasing concern, strategies to reduce the dose or eliminate the need for these drugs are warranted. Lipo-CRX is a formulation in which the TLR4 agonist CRX-527 is incorporated into lipid membranes in liposomes. Lipo-CRX is less inflammatory than either CRX-527 or LPS, but retains unique capacity to enhance host defense responses. We compared lipo-CRX to other agonists

Indexed as

Brucella abortusBrucellosisAnimalsCattleEscherichia coliGlucosamineImmunity, InnateLipopolysaccharidesLiposomesMammalsMiceOrganophosphorus CompoundsToll-Like Receptor 4AGP 527GlucosamineLipopolysaccharidesLiposomesOrganophosphorus CompoundsTlr4 protein, mouseToll-Like Receptor 4AdjuvantantibioticsBrucellabrucellosisinnate immunity

Identifiers

PMID37083049
PMCPMC10331211
OpenAlexW4366603305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.