Evidence map›Paper›PMID 37082956›Full record

ArticleJournal of neurotrauma2023

Early Signs of Elevated Intracranial Pressure on Computed Tomography Correlate With Measured Intracranial Pressure in the Intensive Care Unit and Six-Month Outcome After Moderate to Severe Traumatic Brain Injury.

Tyler J Harder, Owen P Leary, Zhihui Yang, Brandon Lucke-Wold, David D Liu, Megan E H Still, Miao Zhang, Sharon D Yeatts, Jason W Allen, David W Wright and 2 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Tyler J HarderDepartment of Emergency Medicine, Brown University, Providence, Rhode Island, USA.
Owen P LearyDepartment of Neurosurgery, Brown University, Providence, Rhode Island, USA.
Zhihui YangDepartment of Neurosurgery, University of Florida, Gainesville, Florida, USA.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, Florida, USA.
David D LiuDepartment of Neurosurgery, Brown University, Providence, Rhode Island, USA.
Megan E H StillDepartment of Neurosurgery, University of Florida, Gainesville, Florida, USA.
Miao ZhangDepartment of Information Systems and Operation Management, University of Florida, Gainesville, Florida, USA.
Sharon D YeattsDepartment of Biostatistics, Medical University of South Carolina, Charleston, South Carolina, USA.
Jason W AllenDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA.
David W WrightDepartment of Emergency Medicine, Emory University, Atlanta, Georgia, USA.
Derek MerckDepartment of Radiology, University of Florida, Gainesville, Florida, USA.
Lisa H MerckDepartment of Neurosurgery, Brown University, Providence, Rhode Island, USA.
University of Florida · USBrown University · USEmory University · USBrigham and Women's Hospital · USMedical University of South Carolina · USVirginia Commonwealth University · US

Funding

Neurologic Emergencies Treatment Trials Network: Clinical Coordinating CenterU01NS056975 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARSAN, WILLIAM G · 2006 to 2015
$40.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs....U10NS059032 · NINDS · EMORY UNIVERSITY · PI WRIGHT, DAVID W · 2007 to 2016
$2.5M
NCATS NIH HHS UL1 TR000454NINDS NIH HHS U01 NS056975NINDS NIH HHS U10 NS059032
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Early triage and treatment after TBI have been shown to improve outcome. Identifying patients at risk for increased intracranial pressure (ICP) via baseline computed tomography (CT) , however, has not been validated previously in a prospective dataset. We hypothesized that acute CT findings of elevated ICP, combined with direct ICP measurement, hold prognostic value in terms of six-month patient outcome after TBI. Data were obtained from the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECTIII) multi-center clinical trial. Baseline CT scans for 881 participants were individually reviewed by a blinded central neuroradiologist. Five signs of elevated ICP were measured (sulcal obliteration, lateral ventricle compression, third ventricle compression, midline shift, and herniation). Associations between signs of increased ICP and outcomes (six-month functional outcome and death) were assessed. Secondary analyses of 354 patients with recorded ICP monitoring data available explored the relationships between hemorrhage phenotype/anatomic location, sustained ICP ≥20 mm Hg, and surgical intervention(s). Univariate and multi-variate logistic/linear regressions were performed;

Indexed as

Brain Injuries, TraumaticIntracranial HypertensionHumansIntensive Care UnitsIntracranial PressureProspective StudiesTomography, X-Ray Computedfunctional outcomegoal directed therapyintracranial pressuremortalitypredictive modelingtraumatic brain injury

Identifiers

PMID37082956
PMCPMC10458381
OpenAlexW4366603496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.