ArticleFrontiers in cellular and infection microbiology2023
Microbiome and metabolome associated with white spot lesions in patients treated with clear aligners.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Impact of Clear Aligners on the Oral Microbiome: A Systematic Review of Current Evidence.Clinical and experimental dental research · 2026Pooled it
- Oral Microbiome and Metabolome Changes During Orthodontic Treatments: A Systematic Review of Limited Clinical Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Orthodontic treatment and oral microbiota changes: a systematic review of oral dysbiosis revealed by 16S rRNA gene analysis.The Angle orthodontist · 2025Pooled it
- Salivary parameters in individuals undergoing orthodontic treatment with clear aligners: a scoping review.Evidence-based dentistry · 2026Article
- A DMAHDM-herbal hybrid gargle for orthodontic-associated complications via oral microbiota regulation, inflammation inhibition, and enamel protection.Materials today. Bio · 2026Article
- Femtosecond laser-induced micro/nanostructures loaded with silver nanoparticles on clear aligners prevent bacterial infection.BMC oral health · 2026Article
- Incidence and distribution of white spot lesions after clear aligner versus fixed appliance therapy : A retrospective digital photograph and intraoral scan analysis.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Article
- A prospective cohort study exploring salivary microbial predictors of white spot lesions during fixed orthodontic treatment.Journal of oral microbiology · 2026Article
- Spectrophotometric, Periodontal and Subjective Evaluations on Five Different Products for Clear Aligners Cleansing: Randomised Clinical Trial.International journal of dentistry · 2026Article
- Evaluating the Impact of Clear Dental Aligners on Dental and Periodontal Conditions, Oral Microbial Patterns, and the Immune System.Advances in experimental medicine and biology · 2026Review
- Integrated salivary microbiome and metabolome profiling reveals ecological and functional alterations in severe early childhood caries.Journal of translational medicine · 2025Article
- Metabolomic and metagenomic analyses reveal distinct microenvironmental signatures between clear aligner-associated and tooth surface dental plaque.BMC oral health · 2025Article
- Dual-functionality of Nocardiopsis alba B57 in biocontrol and plant growth: a metabolomic approach to agricultural sustainability.NPJ biofilms and microbiomes · 2025Article
- Fabrication of N-halamine coatings with long-lasting bacterial inhibition and bacterial biofilm disruption functions for invisible aligner applications.Materials today. Bio · 2025Article
- Saliva metabolomics: a non-invasive frontier for diagnosing and managing oral diseases.Journal of translational medicine · 2025Review
- Biofilm Composition Changes During Orthodontic Clear Aligners Compared to Multibracket Appliances: A Systematic Review.Microorganisms · 2025Review
- Expert consensus on the clinical strategies for orthodontic treatment with clear aligners.International journal of oral science · 2025Review
- Microbiome variability and role ofJournal of oral microbiology · 2025Article
- In vitro evaluation of biofilm formation by Streptococcus mutans and Candida albicans in orthodontic aligners.Dental press journal of orthodontics · 2025Article
- A comparison of the alterations of oral microbiome with fixed orthodontic therapy and clear aligners: a systematic review.Journal of oral microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White spot lesions (WSLs) have long been a noteworthy complication during orthodontic treatment. Recently, an increasing number of orthodontists have found that adolescents undergoing orthodontic treatment with clear aligners are at a higher risk of developing WSLs. The oral microbiota and metabolites are considered the etiologic and regulatory factors of WSLs, but the specific impact of clear aligners on the oral microbiota and metabolites is unknown. This study investigated the differences in the salivary microbiome and metabolome between adolescents with and without WSLs treated with clear aligners. Fifty-five adolescents (aged 11-18) with Invisalign appliances, 27 with and 28 without WSLs, were included. Saliva samples were analyzed using 16S rRNA gene sequencing and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS); the data were further integrated for Spearman correlation analysis. The relative abundances of 14 taxa, including
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.