Evidence map›Paper›PMID 37082581›Full record

ArticleBBA advances2022

Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses.

Graeme Benzie, Kristen Bouma, Taylor Battellino, Steven Cooper, Rick Hemming, Wafa Kammouni, Lin Liu, Cuong Do, Mazdak Khajehpour, Helene Perreault and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Graeme BenzieDepartment of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Kristen BoumaDepartment of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Taylor BattellinoDepartment of Chemistry, University of Manitoba, Winnipeg R3T 2N2, Canada.
Steven CooperBiochemistry and Medical Genetics, University of Manitoba, Canada.
Rick HemmingBiochemistry and Medical Genetics, University of Manitoba, Canada.
Wafa KammouniBiochemistry and Medical Genetics, University of Manitoba, Canada.
Lin LiuM6P Therapeutics, 20 S. Sarah St., St. Louis, MO 63018, United States.
Cuong DoM6P Therapeutics, 20 S. Sarah St., St. Louis, MO 63018, United States.
Mazdak KhajehpourDepartment of Chemistry, University of Manitoba, Winnipeg R3T 2N2, Canada.
Helene PerreaultDepartment of Chemistry, University of Manitoba, Winnipeg R3T 2N2, Canada.
Stuart KornfeldWashington University School of Medicine in St. Louis, Department of Biochemistry & Molecular Biophysics, United States.
Barbara Triggs-RaineBiochemistry and Medical Genetics, University of Manitoba, Canada.
Brian L MarkDepartment of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
University of Manitoba · CAAPT Therapeutics (United States) · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tay-Sachs and Sandhoff diseases are genetic disorders resulting from mutations in

Identifiers

PMID37082581
PMCPMC10074939
OpenAlexW4200505416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.