Evidence map›Paper›PMID 37082447›Full record

ArticleFrontiers in neurology2023

Trajectories of interleukin 10 and heart fatty acid-binding protein levels in traumatic brain injury patients with or without extracranial injuries.

Toni J U Niiranen, Anne-Cécile Chiollaz, Riikka S K Takala, Miko Voutilainen, Olli Tenovuo, Virginia F J Newcombe, Henna-Riikka Maanpää, Jussi Tallus, Mehrbod Mohammadian, Iftakher Hossain and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Toni J U NiiranenDepartment of Clinical Neurosciences, University of Turku, Turku, Finland.
Anne-Cécile ChiollazDepartment of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Riikka S K TakalaPerioperative Services, Intensive Care Medicine, and Pain Management, Turku University Hospital and University of Turku, Turku, Finland.
Miko VoutilainenDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland.
Olli TenovuoDepartment of Clinical Neurosciences, University of Turku, Turku, Finland.
Virginia F J NewcombeDivision of Anaesthesia, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.
Henna-Riikka MaanpääTurku Brain Injury Center, Turku University Hospital, Turku, Finland.
Jussi TallusDepartment of Clinical Neurosciences, University of Turku, Turku, Finland.
Mehrbod MohammadianTurku Brain Injury Center, Turku University Hospital, Turku, Finland.
Iftakher HossainDepartment of Clinical Neurosciences, University of Turku, Turku, Finland.
Mark van GilsFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
David K MenonDivision of Anaesthesia, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.
Peter J HutchinsonDepartment of Clinical Neurosciences, Neurosurgery Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.
Jean-Charles SanchezDepartment of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Jussi P PostiDepartment of Clinical Neurosciences, University of Turku, Turku, Finland.
Turku University Hospital · FIUniversity of Turku · FIUniversity of Cambridge · GBUniversity of Geneva · CHTampere University · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have gained interest as diagnostic biomarkers of traumatic brain injury (TBI), but factors affecting their blood levels in patients with moderate-to-severe TBI are largely unknown. Objective: To investigate the trajectories of IL-10 and H-FABP between TBI patients with and without extracranial injuries (ECI); to investigate if there is a correlation between the levels of IL-10 and H-FABP with the levels of inflammation/infection markers C-reactive protein (CRP) and leukocytes; and to investigate if there is a correlation between the admission level of H-FABP with admission levels of cardiac injury markers, troponin (TnT), creatine kinase (CK), and creatine kinase MB isoenzyme mass (CK-MBm). Materials and methods: The admission levels of IL-10, H-FABP, CRP, and leukocytes were measured within 24 h post-TBI and on days 1, 2, 3, and 7 after TBI. The admission levels of TnT, CK, and CK-MBm were measured within 24 h post-TBI. Results: There was a significant difference in the concentration of H-FABP between TBI patients with and without ECI on day 0 (48.2 ± 20.5 and 12.4 ± 14.7 ng/ml, Conclusion: Inflammatory reactions during the early days after a TBI do not significantly confound the use of IL-10 and H-FABP as TBI biomarkers. Extracranial injuries and cardiac sources may influence the levels of H-FABP in patients with moderate-to-severe TBI.

Indexed as

C-reactive proteinextracranial injuryH-FABPinterleukin-10traumatic brain injury

Identifiers

PMID37082447
PMCPMC10111051
OpenAlexW4362560650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.