ArticleOsteoporosis and sarcopenia2023
Development and validation of the Chinese osteoporosis screening algorithm (COSA) in identification of people with high risk of osteoporosis.
Article in Osteoporosis and sarcopenia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 11 citations in OpenAlex.
- Osteoporosis screening and management framework for community-based primary care in Hong Kong: A Delphi consensus study.Osteoporosis and sarcopenia · 2026Article
- Machine learning-based screening model for osteoporosis in Chinese postmenopausal women: a nationwide study with prospective fracture validation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Nurse-led risk-based primary healthcare intervention in midlife women's health management in Hong Kong: a stepped-wedge cluster randomized controlled trial protocol.BMC primary care · 2026Article
- Predicting Hip Osteoporosis with Routine Demographic and Biochemical Data: The Shao HipOsteoRisk Model.Clinical interventions in aging · 2026Observational
- Explainable machine learning for osteoporosis detection in patients with osteopenia: model development and validation using routine clinical data from an Asian cohort.Frontiers in endocrinology · 2026Article
- Asia-Pacific consensus for the management of osteoporosis in men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- A predictive nomogram for selective screening of asymptomatic vertebral fractures: The Vietnam Osteoporosis Study.Osteoporosis and sarcopenia · 2025Article
- Enhancing osteoporosis management through risk assessment tools.Osteoporosis and sarcopenia · 2024Article
- Assessing the utility of osteoporosis self-assessment tool for Asians in patients undergoing hip surgery.Osteoporosis and sarcopenia · 2024Article
- Identification of people with high risk of osteoporosis in Asia.Osteoporosis and sarcopenia · 2023Article
- Reply on "Identification of people with high risk of osteoporosis in Asia".Osteoporosis and sarcopenia · 2023Article
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6 authors at 4 institutions in 1 country.
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Abstract
Objectives: To enhance the public awareness and facilitate diagnosis of osteoporosis, we aim to develop a new Chinese Osteoporosis Screening Algorithm (COSA) to identify people at high risk of osteoporosis. Methods: A total of 4747 postmenopausal women and men aged ≥ 50 from the Hong Kong Osteoporosis Study were randomly split into a development (N = 2373) and an internal validation cohort (N = 2374). An external validation cohort comprising 1876 community-dwelling subjects was used to evaluate the positive predictive value (PPV). Results: Among 11 predictors included, age, sex, weight, and history of fracture were significantly associated with osteoporosis after correction for multiple testing. Age- and sex-stratified models were developed due to the presence of significant sex and age interactions. The area under the curve of the COSA in the internal validation cohort was 0.761 (95% CI, 0.711-0.811), 0.822 (95% CI, 0.792-0.851), and 0.946 (95% CI, 0.908-0.984) for women aged < 65, women aged ≥ 65, and men, respectively. The COSA demonstrated improved reclassification performance when compared to Osteoporosis Self-Assessment Tool for Asians. In the external validation cohort, the PPV of COSA was 40.6%, 59.4%, and 19.4% for women aged < 65, women aged ≥ 65, and men, respectively. In addition, COSA > 0 was associated with an increased 10-year risk of hip fracture in women ≥ 65 (OR, 4.65; 95% CI, 2.24-9.65) and men (OR, 11.51; 95% CI, 4.16-31.81). Conclusions: We have developed and validated a new osteoporosis screening algorithm, COSA, specific for Hong Kong Chinese.
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