Evidence map›Paper›PMID 37082351›Full record

ArticleAdvanced synthesis & catalysis2023

Organic Acid to Nitrile: A Chemoenzymatic Three-Step Route.

Margit Winkler, Melissa Horvat, Astrid Schiefer, Victoria Weilch, Florian Rudroff, Miroslav Pátek, Ludmila Martínková

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced synthesis & catalysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Margit WinklerInstitute of Molecular Biotechnology Graz University of Technology Petersgasse 14 A-8010 Graz Austria.ORCID 0000-0002-0754-9704
Melissa HorvatInstitute of Molecular Biotechnology Graz University of Technology Petersgasse 14 A-8010 Graz Austria.
Astrid SchieferInstitute of Applied Synthetic Chemistry TU Wien Getreidemarkt 9/OC-163 A-1060 Vienna Austria.
Victoria WeilchInstitute of Molecular Biotechnology Graz University of Technology Petersgasse 14 A-8010 Graz Austria.
Florian RudroffInstitute of Applied Synthetic Chemistry TU Wien Getreidemarkt 9/OC-163 A-1060 Vienna Austria.ORCID 0000-0002-6680-8200
Miroslav PátekInstitute of Microbiology of the Czech Academy of Sciences Vídeňská 1083 CZ-142 20 Prague Czech Republic.
Ludmila MartínkováInstitute of Microbiology of the Czech Academy of Sciences Vídeňská 1083 CZ-142 20 Prague Czech Republic.
Institute of Molecular Biotechnology · ATCzech Academy of Sciences · CZTU Wien · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for a whole range of different reactions. We report a cyanide free chemoenzymatic cascade for nitrile synthesis. The reaction pathway starts with a reduction of carboxylic acid to aldehyde by carboxylate reductase enzymes (CARs) applied as living cell biocatalysts. The second - chemical - step includes

Indexed as

aldoxime dehydratase (Oxd)carboxylic acid reductase (CAR)chemoenzymatic synthesiscyanide-free nitrile synthesisnitrilesoxidoreductases

Identifiers

PMID37082351
PMCPMC10107818
OpenAlexW4313298743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.