Evidence map›Paper›PMID 37082260›Full record

ArticleBBA advances2023

Neuropathic pain changes the output of rat lamina I spino-parabrachial neurons.

Volodymyr Krotov, Kirill Agashkov, Sergii Romanenko, Kostiantyn Koroid, Marharyta Krasniakova, Pavel Belan, Nana Voitenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Volodymyr KrotovDepartment of Sensory Signaling, Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine.
Kirill AgashkovDepartment of Sensory Signaling, Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine.
Sergii RomanenkoDepartment of Sensory Signaling, Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine.
Kostiantyn KoroidDepartment of Sensory Signaling, Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine.
Marharyta KrasniakovaDepartment of Sensory Signaling, Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine.
Pavel BelanDepartment of Molecular Biophysics, Bogomoletz Institute of Physiology, NASU, Kyiv, Ukraine.
Nana VoitenkoKyiv Academic University, NASU, Kyiv, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

• Spared nerve injury (SNI) altered the action potential (AP) output of lamina I spino-parabrachial neurons (SPNs) without affecting their resting potential or membrane resistance. • In one-third of SPNs, high-threshold dorsal root stimulation elicited persistent AP firing which was never observed in cells from naïve animals. • 38% of SPNs from SNI rats showed spontaneous persistent AP firing. • After SNI low- and high-output SPNs were no longer nociceptive-specific as part of them responded with APs to low-threshold stimulation. • These SNI-induced changes of SPN output might represent cellular mechanisms for neuropathy-associated allodynia, hyperalgesia, and spontaneous pain.

Indexed as

Action potentialAllodyniaHyperalgesiaLamina INeuropathic painNociceptionSpared nerve injurySpinal cordSpino-parabrachial projection neuronsSpontaneous pain

Identifiers

PMID37082260
PMCPMC10074952

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.