ArticleCell genomics2023
Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing.
Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- Evolving conservation: The role of unconventional approaches to restore contemporary vertebrate populations and genomic biodiversity.The Journal of heredity · 2026Review
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- In silico genome transplants and the cis-regulatory basis of biodiversity.Trends in genetics : TIG · 2026Review
- Sign Epistasis Can be Absent in Multi-peaked Landscapes With Neutral Mutations.Genome biology and evolution · 2026Article
- Experimental evolution in an era of molecular manipulation.Nature reviews. Genetics · 2026Review
- SELECT: high-precision genome editing strategy via integration of CRISPR-Cas and DNA damage response for cross-species applications.Nucleic acids research · 2025Article
- Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster.G3 (Bethesda, Md.) · 2025Article
- Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.Genetics · 2025Article
- Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.bioRxiv : the preprint server for biology · 2024Article
- Gain- and loss-of-function alleles within signaling pathways lead to phenotypic diversity among individuals.iScience · 2024Article
- Epistasis and pleiotropy-induced variation for plant breeding.Plant biotechnology journal · 2024Review
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- Genome-scale analysis of interactions between genetic perturbations and natural variation.Nature communications · 2024Article
- The distribution of fitness effects during adaptive walks using a simple genetic network.PLoS genetics · 2024Article
- Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis.BioData mining · 2024Article
- Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes.Human genomics · 2024Article
- Genome-scale analysis of interactions between genetic perturbations and natural variation.bioRxiv : the preprint server for biology · 2024Article
- Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size.Science (New York, N.Y.) · 2023Article
- Gene-by-environment interactions are pervasive among natural genetic variants.Cell genomics · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The phenotypic effect of any genetic variant can be altered by variation at other genomic loci. Known as epistasis, these genetic interactions shape the genotype-phenotype map of every species, yet their origins remain poorly understood. To investigate this, we employed high-throughput genome editing to measure the fitness effects of 1,826 naturally polymorphic variants in four strains of
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