Evidence map›Paper›PMID 37082114›Full record

ArticleFrontiers in genetics2022

Non-coding regions of nuclear-DNA-encoded mitochondrial genes and intergenic sequences are targeted by autoantibodies in breast cancer.

Deya Obaidat, Roberta Giordo, Erica L Kleinbrink, Emilia Banisad, Lawrence I Grossman, Rooshan Arshad, Azadeh Stark, Marie-Claire Maroun, Leonard Lipovich, Félix Fernandez-Madrid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Deya ObaidatDepartment of Internal Medicine, Division of Rheumatology, Wayne State University School of Medicine, Detroit, MI, United States.
Roberta GiordoDepartment of Basic Medical Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Erica L KleinbrinkCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States.
Emilia BanisadDepartment of Internal Medicine, Division of Rheumatology, Wayne State University School of Medicine, Detroit, MI, United States.
Lawrence I GrossmanCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States.
Rooshan ArshadCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, United States.
Azadeh StarkDepartment of Pathology, Henry Ford Health System, Detroit, MI, United States.
Marie-Claire MarounDepartment of Internal Medicine, Division of Rheumatology, Wayne State University School of Medicine, Detroit, MI, United States.
Leonard LipovichDepartment of Basic Medical Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Félix Fernandez-MadridDepartment of Internal Medicine, Division of Rheumatology, Wayne State University School of Medicine, Detroit, MI, United States.
Wayne State University · USHenry Ford Health System · USMohammed Bin Rashid University of Medicine and Health Sciences · AEShenzhen Weiguang Biological Products (China) · CN

Funding

Life, Death, and Function: The Primate-Specific Long Non-Coding RNA TranscriptomeDP2CA196375 · NCI · WAYNE STATE UNIVERSITY · PI LIPOVICH, LEONARD · 2014 to 2014
$2.3M
Development and Validation of a Panel of Breast Cancer for the Early Diagnosis ofR01CA122277 · NCI · WAYNE STATE UNIVERSITY · PI FERNANDEZ-MADRID, FELIX RODOLFO · 2008 to 2010
$1.7M
NCI NIH HHS DP2 CA196375NCI NIH HHS R01 CA122277
6 · The paper itself

Abstract

Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation in autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (

Indexed as

autoimmunitybreast cancercarcinogenesislong non-coding RNAmitochondriaphage display

Identifiers

PMID37082114
PMCPMC10111166
OpenAlexW4361299019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.