Evidence map›Paper›PMID 37081854›Full record

ArticleMolecular therapy. Methods & clinical development2023

HDAd6/35++ - A new helper-dependent adenovirus vector platform for

Hongjie Wang, Aphrodite Georgakopoulou, Wenli Zhang, Jiho Kim, Sucheol Gil, Anja Ehrhardt, André Lieber

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Durable antiviral protection via directMolecular therapy. Advances · 2026
    Article
  3. Molecular therapy. Advances · 2026
    Article
  4. Article
  5. Review
  6. Molecular therapy. Methods & clinical development · 2025
    Article
  7. The multiverse of CD46 and oncologic interactions.The Journal of clinical investigation · 2025
    Review
  8. Molecular therapy. Methods & clinical development · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Swapping the serotype: A novel helper-dependent adenoviral vector platform forMolecular therapy. Methods & clinical development · 2023
    Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hongjie WangUniversity of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA.
Aphrodite GeorgakopoulouUniversity of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA.
Wenli ZhangVirology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, Witten/Herdecke University, 58453 Witten, Germany.
Jiho KimUniversity of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA.
Sucheol GilUniversity of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA.
Anja EhrhardtVirology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, Witten/Herdecke University, 58453 Witten, Germany.
André LieberUniversity of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA.
University of Washington Medical Center · USWitten/Herdecke University · DEUniversity of Washington · US

Funding

Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
In Vivo Hematopoietic Stem Cell Gene Therapy of Beta-Thalassemia and Sickle Cell DiseaseR01HL130040 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIEBER, ANDRE MICHAEL · 2016 to 2024
$4.3M
In vivo HSC gene therapy using a multi-modular HDAd vector for HIV cureR01AI174304 · NIAID · UNIVERSITY OF WASHINGTON · PI HANS-PETER KIEM, ANDRE Michael LIEBER · 2023 to 2026
$4.3M
Approach for in vivo gene delivery into hematopoietic stem cells for hemophilia A therapyR01HL141781 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIEBER, ANDRE MICHAEL · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL130040NHLBI NIH HHS R01 HL141781NIAID NIH HHS R01 AI174304NIDDK NIH HHS U54 DK106829
6 · The paper itself

Abstract

In previous studies, we achieved safe and efficient

Indexed as

adenovirus serotype 6helper-dependent adenovirus vectorin vivo HSC gene therapyserum prevalence

Identifiers

PMID37081854
PMCPMC10111954
OpenAlexW4328097591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.