ArticleFrontiers in medicine2023
Association between treatment failure in patients with early syphilis and penicillin resistance-related gene mutations of
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026Review
- Susceptibility to Penicillin G and Ceftriaxone in 3 Clinical Treponema pallidum Isolates Is Not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein.Sexually transmitted diseases · 2026Article
- Molecular Diagnosis of Syphilis in Brazilian Ambulatory Patients: Detection ofMicroorganisms · 2026Article
- Rapid visual detection of Treponema pallidum using the RPA-CRISPR/Cas12a system.Scientific reports · 2026Article
- Resistance to ceftriaxone and penicillin G among contemporary syphilis strains confirmed by natural in vitro mutagenesis.Communications medicine · 2025Article
- Expanding Horizons in Syphilis Treatment: Challenges, Advances, and Opportunities for Alternative Antibiotics.Current HIV/AIDS reports · 2025Review
- The Critical Role of Penicillin in Syphilis Treatment and Emerging Resistance Challenges.Diseases (Basel, Switzerland) · 2025Review
- Molecular investigation ofMicrobiology spectrum · 2024Article
- Prevalence and Treatment Outcomes of Syphilis among People with Human Immunodeficiency Virus (HIV) Engaging in High-Risk Sexual Behavior: Real World Data from Northern Greece, 2019-2022.Microorganisms · 2024Article
- Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention.Frontiers in neurology · 2023Review
- Resurgence of sexually transmitted infections in India.Indian journal of sexually transmitted diseases and AIDSReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The widespread occurrence of syphilis remains a global public health problem. Although penicillin has been recommended as the first-line therapy for syphilis for more than 70 years, treatment failure occurs in 10-20% of patients with early syphilis. Recent studies have reported varied single-nucleotide polymorphisms (SNPs) of Methods: A multicentre nested case-control study is designed, and patients who are diagnosed with early syphilis and treated with penicillin will be recruited for the study cohort. Before the first treatment, baseline information and biological specimens will be collected from the subjects, and serological tests for syphilis will be performed. Each participant will be followed up at 1, 3, 6, 9, and 12 months after the first treatment, and the clinical manifestations and serum non-treponemal test titres will be evaluated at each follow-up. Patients who will fail treatment are defined as cases, and those who will respond to treatment are defined as controls. Tests for SNPs related to penicillin-binding proteins and Tp47 will be performed in these cases and controls. Survival analysis is used performed to identify gene mutations of Discussion: This protocol provides a practical clinical study design that illustrates the role of gene mutations of
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