Evidence map›Paper›PMID 37081806›Full record

ArticleLeukemia & lymphoma2023

Pdx1 expression in hematopoietic cells activates

Morgan T Walcheck, Manabu Nukaya, Erik A Ranheim, Kristina A Matkowskyj, Sean Ronnekleiv-Kelly

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Morgan T WalcheckDepartment of Surgery, Division of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, K3/705 CSC, Madison, WI, USA.
Manabu NukayaDepartment of Surgery, Division of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, K3/705 CSC, Madison, WI, USA.
Erik A RanheimUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Kristina A MatkowskyjUniversity of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Sean Ronnekleiv-KellyDepartment of Surgery, Division of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, K3/705 CSC, Madison, WI, USA.ORCID 0000-0001-6664-996X
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA014520NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

The highly utilized KC model has a reported lethality rate of about 30%, which has been attributed to pancreas cancer. However, a competing cause of lethality in KC mice is due to the activation of mutant-

Indexed as

Pancreatic NeoplasmsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaAnimalsHomeodomain ProteinsIntegrasesMiceMice, TransgenicMutationProto-Oncogene Proteins p21(ras)Trans-ActivatorsCre recombinaseHomeodomain ProteinsHras protein, mouseIntegrasespancreatic and duodenal homeobox 1 proteinProto-Oncogene Proteins p21(ras)Trans-ActivatorshematopoieticKC miceKrasPdx1T-ALLT-cell acute lymphoblastic leukemia

Identifiers

PMID37081806
PMCPMC10503568
OpenAlexW4366602562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.