Evidence map›Paper›PMID 37081745›Full record

ReviewEmerging infectious diseases2023

Trends in and Risk Factors for Recurrent Clostridioides difficile Infection, New Haven County, Connecticut, USA, 2015-2020.

Chinenye M Okafor, Paula Clogher, Danyel Olson, Linda Niccolai, James Hadler

Open access · diamondAbstract readReview
In one paragraph

Review in Emerging infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Global burden and trends of theAnnals of medicine · 2025
    Observational
  3. Article
  4. Review
  5. The evolving landscape of live biotherapeutics in the treatment of Clostridioides difficile infection.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
  6. Potent Antimicrobial Activity ofAntibiotics (Basel, Switzerland) · 2025
    Article
  7. Article
  8. A Review of Therapies forAntibiotics (Basel, Switzerland) · 2024
    Review
  9. Gene Expression Dysregulation in Whole Blood of Patients withInternational journal of molecular sciences · 2024
    Article
  10. Therapeutics involved in managing initial and recurrentWorld journal of gastrointestinal pharmacology and therapeutics · 2024
    Review
  11. Characteristics of Patients With InitialOpen forum infectious diseases · 2024
    Article
  12. Advances in diagnostic assays forFrontiers in cellular and infection microbiology · 2024
    Review
  13. Biofilm Formation ofMicroorganisms · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chinenye M Okafor
Paula Clogher
Danyel Olson
Linda Niccolai
James Hadler
University of California, Irvine · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Recurrent Clostridioides difficile infection (RCDI) causes an increased burden on the healthcare system. We calculated RCDI incidence and identified factors associated with RCDI cases in New Haven County, Connecticut, USA, during 2015-2020 by using data from population-based laboratory surveillance. A subset of C. difficile cases had complete chart reviews conducted for RCDI and potentially associated variables. RCDI was defined as a positive C. difficile specimen occurring 2-8 weeks after incident C. difficile infection. We compared cases with and without RCDI by using multiple regression. RCDI occurred in 12.0% of 4,301 chart-reviewed C. difficile cases, showing a U-shaped time trend with a sharp increase in 2020, mostly because of an increase in hospital-onset cases. Malignancy (odds ratio 1.51 [95% CI 1.11-2.07]) and antecedent nitrofurantoin use (odds ratio 2.37 [95% CI 1.23-4.58]) were medical risk factors for RCDI. The 2020 increase may reflect the impact of the COVID-19 pandemic.

Indexed as

Clostridioides difficileClostridium InfectionsCOVID-19ConnecticutHumansPandemicsRecurrenceRetrospective StudiesRisk Factorsantimicrobial resistancebacteriabacterial infectionsCDIchronic disease epidemiologyClostridioides difficileConnecticutmalignancynitrofurantoinnosocomial infectionsrecurrent CDIrecurrent Clostridioides difficileUnited States

Identifiers

PMID37081745
PMCPMC10124664
OpenAlexW4366602744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.