Evidence map›Paper›PMID 37081534›Full record

ArticleBMC public health2023

Suubi + Adherence4Youth: a study protocol to optimize the Suubi Intervention for Adherence to HIV treatment for youth living with HIV in Uganda.

Fred M Ssewamala, John A Sauceda, Rachel Brathwaite, Torsten B Neilands, Proscovia Nabunya, Derek Brown, Ozge Sensoy Bahar, Flavia Namuwonge, Noeline Nakasujja, Allan Mugarura and 4 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05600621 (Suubi+Adherence4Youth), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05600621 naactive not recruitingnot on this map

Suubi+Adherence4Youth: Optimizing the Suubi Intervention for Adherence to HIV Treatment for Youth Living With HIV in Uganda

TypeinterventionalSponsorWashington University School of MedicineRan2023 to 2027Enrolled576ConditionsHIVArmsFinancial Literacy Training (FLT) Workshops, Incentivized Matched Youth Savings Accounts (YSA) with income-generating activities (IGAs), A manualized visual-based intervention for ART adherence and stigma reduction using multiple family group approach (Suubi Cartoon)., Engagement with HIV treatment-experienced role models who share lived experiences of HIV, Standard of Care (SOC)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  5. 'Research ethics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Fred M SsewamalaInternational Center for Child Health and Development, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA. fms1@wustl.edu.
John A SaucedaCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.
Rachel BrathwaiteInternational Center for Child Health and Development, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA.
Torsten B NeilandsCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.
Proscovia NabunyaInternational Center for Child Health and Development, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA.
Derek BrownBrown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA.
Ozge Sensoy BaharInternational Center for Child Health and Development, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA.
Flavia NamuwongeInternational Center for Child Health and Development, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA.
Noeline NakasujjaDepartment of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda.
Allan MugaruraInternational Center for Child Health and Development, Masaka, Uganda.
Abel MwebembeziReach the Youth Uganda, Kampala, Uganda.
Portia NarteyInternational Center for Child Health and Development, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO, 63130, USA.
Barbara MukasaMildmay Uganda, Kampala, Uganda.
Marya GwadzIntervention Innovations Team Lab (IIT-Lab), New York University Silver School of Social Work, New York, NY, USA.
Washington University in St. Louis · USMakerere University · UGMildmay Uganda · UGNew York University · USSan Francisco AIDS Foundation · USUniversity of California, San Francisco · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Training Program for Scientists Conducting Research to Reduce HIV Health DisparitR25MH067127 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily A Arnold, Torsten Brian Neilands · 2003 to 2026
$5.4M
Suubi+Adherence4Youth: Optimizing the Suubi Intervention for Adherence to HIV Treatment for Youth Living with HIV in UgandaR01MH131507 · NIMH · WASHINGTON UNIVERSITY · PI FRED M SSEWAMALA, John Andrew Sauceda · 2022 to 2026
$3.2M
Strengthening Child Health Research Capacity in Resource Constrained Settings: Researcher Resilience Training (RRT)R25MH118935 · NIMH · WASHINGTON UNIVERSITY · PI SEAN JOE, Mary McKernan McKay · 2018 to 2026
$1.5M
NIMH NIH HHS P30 MH062246NIMH NIH HHS R01 MH131507NIMH NIH HHS R25 MH067127NIMH NIH HHS R25 MH118935
6 · The paper itself

Abstract

backgroundSuubi is an evidenced based multi-component intervention that targets psychosocial and economic hardships to improve ART adherence, viral suppression, mental health, family financial stability, and family cohesion for adolescents living with HIV (ALHIV) in Uganda. Suubi was originally tested as a combined package of four components: 1) Financial Literacy Training; 2) incentivized matched Youth Savings Accounts with income-generating activities; 3) a manualized and visual-based intervention for ART adherence and stigma reduction; and 4) engagement with HIV treatment-experienced role models. However, it is unknown if each component in Suubi had a positive effect, how the components interacted, or if fewer components could have produced equivalent effects. Hence, the overall goal of this new study is to identify the most impactful and sustainable economic and psychosocial components across 48 health clinics in Uganda.

methodsA total of 576 ALHIV (aged 11-17 years at enrollment) will be recruited from 48 clinics and each clinic will be randomized to one of 16 study conditions. Each condition represents every possible combination of the 4 components noted above. Assessments will be conducted at baseline, 12, 24, 36 and 48- months post-intervention initiation. Using the multi-phase optimization strategy (MOST), we will identify the optimal combination of components and associated costs for viral suppression, as well as test key mediators and moderators of the component-viral suppression relationship. DISCUSSION: The study is a shift in the paradigm of research to use new thinking to build/un-pack highly efficacious interventions that lead to new scientific knowledge in terms of understanding what drives an intervention's success and how to iterate on them in ways that are more efficient, affordable and scalable. The study advances intervention science for HIV care outcomes globally.

trial registrationThis project was registered at clinicaltrials.gov (NCT05600621) on October, 31, 2022. https://clinicaltrials.gov/ct2/show/NCT05600621.

Indexed as

HIV InfectionsPovertyAdolescentHumansIncomeRandomized Controlled Trials as TopicSexual BehaviorUgandaAdherenceAdolescents living with HIVEconomic empowermentIntervention componentsMultiphase Optimization StrategyOptimizationSuubi + adherenceViral suppressionYouth

Identifiers

PMID37081534
PMCPMC10116736
OpenAlexW4366587723

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.