Evidence map›Paper›PMID 37081460›Full record

Trial reportThe international journal of behavioral nutrition and physical activity2023

Considering depression as a secondary outcome in the optimization of physical activity interventions for breast cancer survivors in the PACES trial: a factorial randomized controlled trial.

Chad D Rethorst, Thomas J Carmody, Keith E Argenbright, Taryn L Mayes, Heidi A Hamann, Madhukar H Trivedi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of behavioral nutrition and physical activity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03060941 (Promoting Activity in Cancer Survivors), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03060941 nacompletednot on this map

Promoting Activity in Cancer Survivors

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2017 to 2020Enrolled355ConditionsPhysical Activity, Breast CancerArmsPhysical activity education, Facility access, Supervised exercise sessions, Self-monitoring (Fitbit), Active living counseling
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Elucidating the mechanism of traditional Chinese medicine formula (Journal of traditional and complementary medicine · 2026
    Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chad D RethorstInstitute for Advancing Health Through Agriculture, Texas A&M Agrilife Research, 17360 Coit Road, Dallas, TX, 75252, USA. chad.rethorst@ag.tamu.edu.ORCID 0000-0002-8168-2829
Thomas J CarmodyDepartment of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Keith E ArgenbrightMoncrief Cancer Institute, University of Texas Southwestern Medical Center, Dallas, TX Fort Worth, TX, USA.
Taryn L MayesDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Heidi A HamannDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Madhukar H TrivediDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepressive symptoms result in considerable burden for breast cancer survivors. Increased physical activity may reduce these burdens but existing evidence from physical activity interventions in equivocal. Furthermore, physical activity intervention strategies may differentially impact depressive symptoms, which should be considered in designing and optimizing behavioral interventions for breast cancer survivors.

methodsThe Physical Activity for Cancer Survivors (PACES) trial enrolled 336 participants breast cancer survivors, who were 3 months to 10 years post-treatment, and insufficiently active (< 150 min of moderate-to-vigorous physical activity per week). Participants were randomly assigned to a combination of 4 intervention strategies in a full-factorial design: 1) supervised exercise sessions, 2) facility access, 3) Active Living Every Day, and 4) Fitbit self-monitoring. Depressive symptoms were assessed at baseline, mid-intervention (3 months), and post-intervention (6 months) using the Quick Inventory for Depressive Symptoms. Change in depressive symptoms were analyzed using a linear mixed-effects model.

resultsResults from the linear mixed-effects model indicated that depressive symptoms decreased significantly across the entire study sample over the 6-month intervention (F = 4.09, p = 0.044). A significant ALED x time interaction indicated participants who received the ALED intervention experienced greater reductions in depressive symptoms (F = 5.29, p = 0.022). No other intervention strategy significantly impacted depressive symptoms.

conclusionsThe ALED intervention consists of strategies (i.e., goal setting, social support) that may have a beneficial impact on depressive symptoms above and beyond the effect of increased physical activity. Our findings highlight the need to consider secondary outcomes when designing and optimizing physical activity interventions.

trial registrationClinicalTrials.gov NCT03060941. Posted February 23, 2017.

Indexed as

Breast NeoplasmsCancer SurvivorsDepressionExerciseFemaleHumansQuality of LifeSurvivorsBehavioral interventionsBreast cancer survivorsDepressionIntervention optimizationPhysical activity

Identifiers

PMID37081460
PMCPMC10120257

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.