Evidence map›Paper›PMID 37081449›Full record

ArticleBMC psychiatry2023

Sleep characteristics and inflammatory markers in women with post-traumatic stress disorder.

Mary Sau Ling Yeh, Dalva Poyares, Ana Teresa D D'Elia, Bruno M Coimbra, Andrea Feijo Mello, Sergio Tufik, Marcelo Feijo Mello

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mary Sau Ling YehDepartment of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Rua Major Maragliano, 241, São Paulo, 04017-030, SP, Brazil. mary.slyeh@gmail.com.
Dalva PoyaresDepartment of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Ana Teresa D D'EliaDepartment of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Rua Major Maragliano, 241, São Paulo, 04017-030, SP, Brazil.
Bruno M CoimbraDepartment of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Rua Major Maragliano, 241, São Paulo, 04017-030, SP, Brazil.
Andrea Feijo MelloDepartment of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Rua Major Maragliano, 241, São Paulo, 04017-030, SP, Brazil.
Sergio TufikDepartment of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Marcelo Feijo MelloDepartment of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Rua Major Maragliano, 241, São Paulo, 04017-030, SP, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSexual violence is one of the most severe traumatic events. It is associated with a higher risk for post-traumatic stress disorder (PTSD) development. Sleep disturbances such as insomnia are frequently reported by PTSD patients and play a key role in the development and course of the disorder. Sleep disturbances are associated with higher levels of pro-inflammatory cytokines emphasizing the importance of sleep studies in individuals with PTSD.

objectivesTo investigate the association between subjective and objective sleep measurements and PTSD symptoms with inflammatory markers in women with PTSD following sexual assault.

methodsIn this longitudinal study fifty-seven women with PTSD were evaluated for sleep measurements and inflammatory markers. Participants completed the Clinician-Administered PTSD Scale, the Beck Depression Inventory, the Pittsburgh Sleep Quality Index (PSQI), and the Insomnia Severity Index. In addition, patients underwent full in-lab polysomnography and serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) measurement. All assessments were performed at baseline and after one year. Patients received pharmacological and/or psychological interventions between baseline and one-year follow-up.

resultsDespite improving PTSD symptoms severity and sleep quality (expressed in PSQI), we found an increase in the inflammatory markers IL-1β, TNF-α, IL-6 and CRP after one year of follow-up. These findings suggest that neurobiological processes may advance independently of PTSD symptoms. We found a significant increase in the levels of IL-1β and TNF-α associated with decreased slow-wave sleep (p = 0.019 and p = 0.018 respectively), IL-6 associated with arousal index (p = 0.024), and CRP associated with insomnia severity (p = 0.012), and sleep duration longer than 6 h per night (p < 0.001).

conclusionsSleep impairments in PTSD may be associated with a gradual and persistent alteration in the immune system, resulting in a progressive inflammatory process. Our results suggest that sleep mechanisms are involved in this incident inflammatory process in young women with PTSD.

Indexed as

Sleep Initiation and Maintenance DisordersSleep Wake DisordersStress Disorders, Post-TraumaticFemaleHumansInterleukin-6Longitudinal StudiesSleepTumor Necrosis Factor-alphaInterleukin-6Tumor Necrosis Factor-alphaCytokinesInflammatory markersPolysomnographyPost-traumatic stress disorderSleep

Identifiers

PMID37081449
PMCPMC10116752
OpenAlexW4366598869

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.