ArticleEuropean radiology2023
Co-existing intracranial and extracranial carotid atherosclerosis predicts large-artery atherosclerosis stroke recurrence: a single-center prospective study utilizing combined head-and-neck vessel wall imaging.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Intracranial atherosclerotic plaque features on vessel wall imaging predict first ever and recurrence of stroke: a meta-analysis.European radiology · 2025Pooled it
- Systemic inflammatory factors combined with HR-VWI-based plaque vulnerability discriminate ischemic phenotypes and predict prognosis in patients with intracranial atherosclerosis.Insights into imaging · 2026Article
- Editorial for "Intracranial Plaque Characteristics and Extracranial Carotid Plaque-RADS Associated With Stroke Recurrence: A High-Resolution Vessel Wall Imaging Study".Journal of magnetic resonance imaging : JMRI · 2026Article
- Intracranial Plaque Characteristics and Extracranial Carotid Plaque-RADS Associated With Stroke Recurrence: A High-Resolution Vessel Wall Imaging Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Expert consensus on intracranial vessel wall MRI in cerebrovascular disease: Society for Magnetic Resonance Angiography recommendations.European radiology · 2026Review
- Association of long-term alcohol consumption with DSA-defined concurrent intracranial and extracranial steno-occlusive involvement in acute ischemic stroke.Frontiers in neurology · 2026Article
- Carotid atherosclerotic plaque vulnerability assessment from angiography-derived radial wall strain validated by MRI.Scientific reports · 2025Article
- Prediction of Occlusion Duration in Nonacute Intracranial Large Artery Through High-Resolution Vessel Wall Imaging.Journal of the American Heart Association · 2025Article
- Quantitative plaque characteristics based on 3D high-resolution vessel wall imaging predict long-term recurrence in intracranial atherosclerotic stroke.Neuroradiology · 2025Article
- Significance of atherosclerotic plaque location in recanalizing non-acute long-segment occlusion of the internal carotid artery.Scientific reports · 2024Article
- Review
- Correlation of intracranial and extracranial carotid atherosclerotic plaque characteristics with ischemic stroke recurrence: a high-resolution vessel wall imaging study.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesIntracranial and extracranial plaque features on high-resolution vessel wall imaging (HR-VWI) are associated with large-artery atherosclerosis (LAA) stroke recurrence. However, most studies have focused on a single vascular bed, and the prognostic value of combined intracranial and extracranial plaque features has yet to be studied. This study aimed to investigate the roles of plaque features, plaque number, and co-existing atherosclerosis in predicting stroke recurrence, utilizing combined head-and-neck HR-VWI.
methodsFrom September 2016 to March 2020, participants with acute LAA ischemic strokes were prospectively enrolled and underwent combined head-and-neck HR-VWI. The participants were followed for stroke recurrence for at least 12 months or until a subsequent event occurred. The imaging features at baseline, including conventional and histogram plaque features, plaque number, and co-existing atherosclerosis, were evaluated. Univariable Cox regression analysis and the least absolute shrinkage and selection operator (lasso) method were used for variable screening. Multivariable Cox regression analyses were used to determine the independent risk factors of stroke recurrence.
resultsA total of 97 participants (59 ± 12 years, 63 men) were followed for a median of 30.9 months, and 21 participants experienced recurrent strokes. Multivariable Cox analysis identified co-existing intracranial high signal on T1-weighted fat-suppressed images (HST1) and extracranial carotid atherosclerosis (HR, 6.12; 95% CI, 2.52-14.82; p = 0.001) as an independent imaging predictor of stroke recurrence.
conclusionCo-existing intracranial HST1 and extracranial carotid atherosclerosis independently predicted LAA stroke recurrence. Combined head-and-neck HR-VWI is a promising technique for atherosclerosis imaging. CLINICAL RELEVANCE STATEMENT: This prospective study using combined head-and-neck HR-VWI highlighted the necessity of both intracranial culprit plaque evaluation and multi-vascular bed assessment, adding value to the prediction of stroke recurrence. KEY POINTS: • This study highlighted the necessity of both intracranial culprit plaque evaluation and multi-vascular bed assessment, adding value to the prediction of stroke recurrence. • This prospective study using combined head-and-neck HR-VWI found co-existing intracranial HST1 and extracranial carotid atherosclerosis to be independent predictors of stroke recurrence.
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