Evidence map›Paper›PMID 37081206›Full record

ArticleNature chemistry2023

Uniform segmented platelet micelles with compositionally distinct and selectively degradable cores.

Zaizai Tong, Yujie Xie, Maria C Arno, Yifan Zhang, Ian Manners, Rachel K O'Reilly, Andrew P Dove

Open access · hybridAbstract read
In one paragraph

Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 119 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Zaizai TongCollege of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, P. R. China.ORCID http://orcid.org/0000-0001-7115-0442
Yujie XieSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK.ORCID http://orcid.org/0000-0002-6024-7019
Maria C ArnoSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK.ORCID http://orcid.org/0000-0003-1734-4777
Yifan ZhangDepartment of Chemistry, University of Victoria, Victoria, British Columbia, Canada.
Ian MannersDepartment of Chemistry, University of Victoria, Victoria, British Columbia, Canada. imanners@uvic.ca.ORCID http://orcid.org/0000-0002-3794-967X
Rachel K O'ReillySchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK. r.oreilly@bham.ac.uk.ORCID http://orcid.org/0000-0002-1043-7172
Andrew P DoveSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK. a.dove@bham.ac.uk.ORCID http://orcid.org/0000-0001-8208-9309
University of Birmingham · GBUniversity of Victoria · CAZhejiang Sci-Tech University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22273087
6 · The paper itself

Abstract

The creation of nanoparticles with controlled and uniform dimensions and spatially defined functionality is a key challenge. The recently developed living crystallization-driven self-assembly (CDSA) method has emerged as a promising route to one-dimensional (1D) and 2D core-shell micellar assemblies by seeded growth of polymeric and molecular amphiphiles. However, the general limitation of the epitaxial growth process to a single core-forming chemistry is an important obstacle to the creation of complex nanoparticles with segmented cores of spatially varied composition that can be subsequently exploited in selective transformations or responses to external stimuli. Here we report the successful use of a seeded growth approach that operates for a variety of different crystallizable polylactone homopolymer/block copolymer blend combinations to access 2D platelet micelles with compositionally distinct segmented cores. To illustrate the utility of controlling internal core chemistry, we demonstrate spatially selective hydrolytic degradation of the 2D platelets-a result that may be of interest for the design of complex stimuli-responsive particles for programmed-release and cargo-delivery applications.

Identifiers

PMID37081206
PMCPMC10239731
OpenAlexW4366588462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.