ArticleNature metabolism2023
Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle.
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Article in Nature metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- "L-Ornithine Liposomal Nanoparticles Targeting the Proline Cycle: A Mechanistic Perspective for Ammonia-Driven Hepatic Encephalopathy".Cell biochemistry and biophysics · 2026Review
- Mechanistic and functional integration of sirtuin deacylases: from substrate specificity to biological outcomes.Glycoconjugate journal · 2026Review
- The functional evaluation of Pichia pastoris hydrolysate as a protein source partial replacement of soybean meal in diets of growing-finishing pigs.Porcine health management · 2026Article
- Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Realgar-Induced CNS Toxicity: Exploring OTC-Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver-Brain Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phytochemistry, Bioactivity, and Toxicological Duality ofMolecules (Basel, Switzerland) · 2025Review
- Sirtuin Family in Acute Kidney Injury: Insights into Cellular Mechanisms and Potential Targets for Treatment.Biomolecules · 2025Review
- Increased urea nitrogen salvaging by a remodeled gut microbiota helps nonhibernating pikas maintain protein homeostasis during winter.PLoS biology · 2025Article
- Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Mechanisms of metabolism-coupled protein modifications.Nature chemical biology · 2025Review
- Dietary Supplementation ofAnimals : an open access journal from MDPI · 2025Article
- Production, Validation, and Exposure Dose Measurement of [Pharmaceutics · 2025Article
- Glutamate Supplementation Regulates Nitrogen Metabolism in the Colon and Liver of Weaned Rats Fed a Low-Protein Diet.Nutrients · 2025Article
- Activation and inhibition of sirtuins: From bench to bedside.Medicinal research reviews · 2025Review
- Article
- Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy.Cell discovery · 2024Article
- Microbiota-gut-liver-brain axis and hepatic encephalopathy.Microbiome research reports · 2024Review
- Protein carbamylation and proteomics: from artifacts to elucidation of biological functions.Frontiers in analytical science · 2024Article
- CPS1 augments hepatic glucagon response through CaMKII/FOXO1 pathway.Frontiers in pharmacology · 2024Article
- Preliminary insights on the metabolomics ofFrontiers in molecular biosciences · 2023Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Song-Hua Hu *The Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-9872-061X
Yu-Yang Feng *The Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Yuan-Xin YangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Hui-Da MaMOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Centre for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0003-2031-4608
Shu-Xian ZhouThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Ya-Nan QiaoThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Kai-Hui ZhangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Lei ZhangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Lin HuangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Yi-Yuan YuanThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-0829-3824
Yan LinThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Xin-Yan ZhangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Yao LiThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China.
Hai-Tao LiMOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Centre for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
Jian-Yuan ZhaoThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China. zhaojy@fudan.edu.cn.ORCID http://orcid.org/0000-0001-9861-0330
Wei XuThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China. xuwei_0706@fudan.edu.cn.ORCID http://orcid.org/0000-0002-9858-589X
Shi-Min ZhaoThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Metabolic Remodelling and Health, State Key Laboratory of Genetic Engineering, and Institutes of Biomedical Sciences, and Children's Hospital of Fudan University, Fudan University, Shanghai, China. zhaosm@fudan.edu.cn.ORCID http://orcid.org/0000-0002-3674-9107
Fudan University · CNCenter for Life Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the regulation of ammonia removal by amino acids remain unclear. Here, we report that SIRT4 acts as a decarbamylase that responds to amino acid sufficiency and regulates ammonia removal. Amino acids promote lysine 307 carbamylation (OTC
Indexed as
Amino AcidsAmmoniaAnimalsCells, CulturedMaleMiceMitochondrial ProteinsProteomicsSirtuinsUreaAmino AcidsAmmoniaMitochondrial ProteinsSIRT4 protein, mouseSirtuinsUrea
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.