Evidence map›Paper›PMID 37081098›Full record

ArticleNature human behaviour2023

Nationwide health, socio-economic and genetic predictors of COVID-19 vaccination status in Finland.

Tuomo Hartonen, Bradley Jermy, Hanna Sõnajalg, Pekka Vartiainen, Kristi Krebs, Andrius Vabalas, FinnGen, Estonian Biobank Research Team, Tuija Leino, Hanna Nohynek and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Nature human behaviour, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 4 countries.

Tuomo Hartonen *Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5535-1698
Bradley Jermy *Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3188-9581
Hanna SõnajalgEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Pekka VartiainenInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-5803-9571
Kristi KrebsEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-0494-2751
Andrius VabalasInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0659-2890
FinnGen
Estonian Biobank Research Team
Tuija LeinoFinnish Institute for Health and Welfare, Helsinki, Finland.
Hanna NohynekFinnish Institute for Health and Welfare, Helsinki, Finland.
Jonas SiveläFinnish Institute for Health and Welfare, Helsinki, Finland.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mark DalyInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Hanna M OllilaInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Markus PerolaFinnish Institute for Health and Welfare, Helsinki, Finland.
Samuli RipattiInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Andrea GannaInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. andrea.ganna@helsinki.fi.ORCID http://orcid.org/0000-0002-8147-240X
Broad Institute · USUniversity of Tartu · EEFinnish Institute for Health and Welfare · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding factors associated with COVID-19 vaccination can highlight issues in public health systems. Using machine learning, we considered the effects of 2,890 health, socio-economic and demographic factors in the entire Finnish population aged 30-80 and genome-wide information from 273,765 individuals. The strongest predictors of vaccination status were labour income and medication purchase history. Mental health conditions and having unvaccinated first-degree relatives were associated with reduced vaccination. A prediction model combining all predictors achieved good discrimination (area under the receiver operating characteristic curve, 0.801; 95% confidence interval, 0.799-0.803). The 1% of individuals with the highest predicted risk of not vaccinating had an observed vaccination rate of 18.8%, compared with 90.3% in the study population. We identified eight genetic loci associated with vaccination uptake and derived a polygenic score, which was a weak predictor in an independent subset. Our results suggest that individuals at higher risk of suffering the worst consequences of COVID-19 are also less likely to vaccinate.

Indexed as

COVID-19COVID-19 VaccinesFinlandHumansIncomeVaccinationCOVID-19 Vaccines

Identifiers

PMID37081098
PMCPMC10365990
OpenAlexW4366549716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.