ArticleNature communications2023
Universal structures for adaptation in biochemical reaction networks.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Effects of synergistic/antagonistic interactions between spermidine (3+) and putrescine (2+) on gene expression through higher-order DNA structural modification.European biophysics journal : EBJ · 2026Article
- Automated Classification of Homeostasis Structure in Input-Output Networks.Bulletin of mathematical biology · 2026Article
- One Earth + One Health: An Agile, Evolutionary, System-of-Systems Convergence Paradigm.Environmental science & technology · 2026Review
- Generative design of synthetic gene circuits for functional and evolutionary properties.NPJ systems biology and applications · 2026Article
- Topological criterion for robust perfect adaptation of reaction fluxes in biological networks.iScience · 2025Article
- Laser capture microdissection.Nature reviews. Methods primers · 2025Article
- A distributed integral control mechanism for regulation of cholesterol concentration in the human retina.Royal Society open science · 2024Article
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- DNA Reaction System That Acquires Classical Conditioning.ACS synthetic biology · 2024Article
- Only a topological method can identify all possible network structures capable of Robust Perfect Adaptation.PLoS computational biology · 2023Article
- Sensitivity analysis of biochemical systems using bond graphs.Journal of the Royal Society, Interface · 2023Article
- Robust homeostasis of cellular cholesterol is a consequence of endogenous antithetic integral control.Frontiers in cell and developmental biology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
At the molecular level, the evolution of life is driven by the generation and diversification of adaptation mechanisms. A universal description of adaptation-capable chemical reaction network (CRN) structures has remained elusive until now, since currently-known criteria for adaptation apply only to a tiny subset of possible CRNs. Here we identify the definitive structural requirements that characterize all adaptation-capable collections of interacting molecules, however large or complex. We show that these network structures implement a form of integral control in which multiple independent integrals can collaborate to confer the capacity for adaptation on specific molecules. Using an algebraic algorithm informed by these findings, we demonstrate the existence of embedded integrals in a variety of biologically important CRNs that have eluded previous methods, and for which adaptation has been observed experimentally. This definitive picture of biological adaptation at the level of intermolecular interactions represents a blueprint for adaptation-capable signaling networks across all domains of life, and for the design of synthetic biosystems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.