ArticleScientific reports2023
Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 43 citations in OpenAlex.
- Prolonged systemic inflammation worsens impairments to astrocyte CaAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mechanistic corticostriatal circuit model predicts learning-dependent fMRI dynamics and individual reward bias in humans.bioRxiv : the preprint server for biology · 2026Article
- Low frequency BOLD oscillations,medRxiv : the preprint server for health sciences · 2025Article
- Prolonged systemic inflammation worsens impairments to astrocyte CabioRxiv : the preprint server for biology · 2025Article
- Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI).Light, science & applications · 2025Article
- A computational approach to evaluate how molecular mechanisms impact large-scale brain activity.Nature computational science · 2025Article
- The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons.Brain sciences · 2025Article
- Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach.PLoS computational biology · 2025Article
- Article
- Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex.Biomedicines · 2024Article
- A multi-scale study of thalamic state-dependent responsiveness.PLoS computational biology · 2024Article
- Astrocyte-mediated neuronal irregularities and dynamics: the complexity of the tripartite synapse.Biological cybernetics · 2024Article
- Article
- Multiscale modeling of neuronal dynamics in hippocampus CA1.Frontiers in computational neuroscience · 2024Article
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional magnetic resonance imaging relies on the coupling between neuronal and vascular activity, but the mechanisms behind this coupling are still under discussion. Recent experimental evidence suggests that calcium signaling may play a significant role in neurovascular coupling. However, it is still controversial where this calcium signal is located (in neurons or elsewhere), how it operates and how relevant is its role. In this paper we introduce a biologically plausible model of the neurovascular coupling and we show that calcium signaling in astrocytes can explain main aspects of the dynamics of the coupling. We find that calcium signaling can explain so-far unrelated features such as the linear and non-linear regimes, the negative vascular response (undershoot) and the emergence of a (calcium-driven) Hemodynamic Response Function. These features are reproduced here for the first time by a single model of the detailed neuronal-astrocyte-vascular pathway. Furthermore, we analyze how information is coded and transmitted from the neuronal to the vascular system and we predict that frequency modulation of astrocytic calcium dynamics plays a key role in this process. Finally, our work provides a framework to link neuronal activity to the BOLD signal, and vice-versa, where neuronal activity can be inferred from the BOLD signal. This opens new ways to link known alterations of astrocytic calcium signaling in neurodegenerative diseases (e.g. Alzheimer's and Parkinson's diseases) with detectable changes in the neurovascular coupling.
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