ArticleNature communications2023
Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 170 papers, 1 of them a synthesis that pooled it.
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Who cites it
170 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep traits and physical activity mediate the causal association between depression and age-related diseases.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Biological age acceleration and cardiovascular-kidney-metabolic syndrome progression: evidence from UK Biobank and NHANES.Renal failure · 2026Article
- Dietary preference, biological aging, and incident dementia: a prospective cohort study.GeroScience · 2026Article
- Plasma proteomic signatures of biological aging and metabolic dysfunction-associated steatotic liver disease risk: a prospective cohort study.Hepatology international · 2026Article
- Mental health disparities in LGBTQIA+ populations: an umbrella review of systematic reviews and meta-analyses.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Biological Aging Mediates the Associations Between Multiple Serum Micronutrients and All-Cause Mortality Among U.S. Adults.Biological trace element research · 2026Article
- Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma.medRxiv : the preprint server for health sciences · 2026Article
- Early Adversity Imprints Multisystem Biological Aging: A Longitudinal Study of Adversity Dimensions and Aging Phenotypes Across Adolescence.Biological psychiatry global open science · 2026Article
- Accelerated biological aging, genetic susceptibility, and the risk of peripheral arterial disease: Evidence from the UK Biobank cohort study.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Cross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank.International journal of rheumatic diseases · 2026Article
- Accelerated Biological Aging, Neurodegenerative Disease, and Mortality in Cardiovascular Disease Patients: Mediation and Modification Analysis.CNS neuroscience & therapeutics · 2026Article
- Early-life exposure to sugar rationing and long-term risk of depression and anxiety: a population-based natural experiment.Molecular psychiatry · 2026Article
- Associations of physical activity bout duration and fragmentation with future dementia, depression, and anxiety: a multi-modal UK Biobank study.Translational psychiatry · 2026Article
- Associations of modifiable risk factors with depression and anxiety in women and men: evidence from the UK Biobank.Translational psychiatry · 2026Article
- Deciphering the obesity paradox in phenotypic age acceleration through thyroid hormone sensitivity: results from NHANES 2007-2010.Hormones (Athens, Greece) · 2026Article
- Methylome-wide association study in blood suggests cell type-specific relationships between DNA methylation and lifetime anxiety.Nature communications · 2026Article
- Early-life determinants of cardiometabolic outcomes and accelerated biological ageing in Colombia.Aging · 2026Article
- Associations between socioeconomic factors and mental symptoms highlight whole-body correlates and pathways.iScience · 2026Article
- Accelerated biological aging and brain structural alterations linking air pollution to dementia risk: a prospective cohort study.The journal of nutrition, health & aging · 2026Article
- Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction.Aging cell · 2026Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank participants. We measured biological age from clinical traits using the KDM-BA and PhenoAge algorithms. At baseline, participants who were biologically older more often experienced depression/anxiety. During a median of 8.7 years of follow-up, participants with older biological age were at increased risk of incident depression/anxiety (5.9% increase per standard deviation [SD] of KDM-BA acceleration, 95% confidence intervals [CI]: 3.3%-8.5%; 11.3% increase per SD of PhenoAge acceleration, 95% CI: 9.%-13.0%). Biological-aging-associated risk of depression/anxiety was independent of and additive to genetic risk measured by genome-wide-association-study-based polygenic scores. Advanced biological aging may represent a potential risk factor for incident depression/anxiety in midlife and older adults and a potential target for risk assessment and intervention.
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