ArticleBrain stimulation
Sustained modulation of primate deep brain circuits with focused ultrasonic waves.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- A human-compatible gradient coil for visualizing ultrasound propagation.Magnetic resonance imaging · 2025Article
- Ultrasound system for precise neuromodulation of human deep brain circuits.Nature communications · 2025Article
- Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation.bioRxiv : the preprint server for biology · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- A Physiological Marker for Deep Brain Ultrasonic Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.Neuron · 2024Article
- Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention.Nature communications · 2024Article
- Remotely controlled drug release in deep brain regions of non-human primates.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Remotely induced electrical modulation of deep brain circuits in non-human primates.Frontiers in human neuroscience · 2024Article
- Transcranial ultrasound stimulation effect in the redundant and synergistic networks consistent across macaques.Network neuroscience (Cambridge, Mass.) · 2024Article
- Controlled ultrasonic interventions through the human skull.Frontiers in human neuroscience · 2024Article
- Remote targeted electrical stimulation.Journal of neural engineering · 2023Article
- Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation.Brain stimulationArticle
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTranscranial focused ultrasound has the potential to noninvasively modulate deep brain circuits and impart sustained, neuroplastic effects.
objectiveBring the approach closer to translations by demonstrating sustained modulation of deep brain circuits and choice behavior in task-performing non-human primates.
methodsLow-intensity transcranial ultrasound of 30 s in duration was delivered in a controlled manner into deep brain targets (left or right lateral geniculate nucleus; LGN) of non-human primates while the subjects decided whether a left or a right visual target appeared first. While the animals performed the task, we recorded intracranial EEG from occipital screws. The ultrasound was delivered into the deep brain targets daily for a period of more than 6 months.
resultsThe brief stimulation induced effects on choice behavior that persisted up to 15 minutes and were specific to the sonicated target. Stimulation of the left/right LGN increased the proportion of rightward/leftward choices. These effects were accompanied by an increase in gamma activity over visual cortex. The contralateral effect on choice behavior and the increase in gamma, compared to sham stimulation, suggest that the stimulation excited the target neural circuits. There were no detrimental effects on the animals' discrimination performance over the months-long course of the stimulation.
conclusionThis study demonstrates that brief, 30-s ultrasonic stimulation induces neuroplastic effects specifically in the target deep brain circuits, and that the stimulation can be applied daily without detrimental effects. These findings encourage repeated applications of transcranial ultrasound to malfunctioning deep brain circuits in humans with the goal of providing a durable therapeutic reset.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.