Evidence map›Paper›PMID 37080416›Full record

ArticleBiological psychiatry2023

Dissociation of Cognitive Effort-Based Decision Making and Its Associations With Symptoms, Cognition, and Everyday Life Function Across Schizophrenia, Bipolar Disorder, and Depression.

Deanna M Barch, Adam J Culbreth, Dror Ben Zeev, Andrew Campbell, Subigya Nepal, Erin K Moran

Open access · greenAbstract read
In one paragraph

Article in Biological psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  8. Review
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  11. Review
  12. Article
  13. Passive sensing of anhedonia and amotivation in a transdiagnostic sample.Journal of psychopathology and clinical science · 2025
    Article
  14. Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025
    Article
  15. Review
  16. Evidence for shallow cognitive maps in schizophrenia.Cognitive, affective & behavioral neuroscience · 2025
    Article
  17. Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Deanna M BarchDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri. Electronic address: dbarch@wustl.edu.
Adam J CulbrethMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, Maryland.
Dror Ben ZeevDepartment of Psychiatry, University of Washington, Seattle, Washington.
Andrew CampbellDepartment of Computer Science, Dartmouth College, Hanover, New Hampshire.
Subigya NepalDepartment of Computer Science, Dartmouth College, Hanover, New Hampshire.
Erin K MoranDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, Missouri.
Dartmouth College · USWashington University in St. Louis · USUniversity of Maryland, Baltimore · USUniversity of Washington · US

Funding

Effort-Based Decision Making and Motivated Behavior in Everyday LifeR37MH066031 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch · 2018 to 2026
$6.5M
Multidisciplinary Schizophrenia Research TrainingT32MH067533 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CARPENTER, WILLIAM T., ELMER, GREGORY I · 2004 to 2025
$4.3M
Schizophrenia, Prefrontal Cortex, and Emotion RegulationR01MH066031 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2004 to 2014
$4.1M
Computational Mechanisms of Effort-Cost Decision-Making in SchizophreniaK23MH126986 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CULBRETH, ADAM J. · 2021 to 2025
$827k
NIMH NIH HHS K23 MH126986NIMH NIH HHS R01 MH066031NIMH NIH HHS R37 MH066031NIMH NIH HHS T32 MH067533
6 · The paper itself

Abstract

backgroundAnhedonia and amotivation are symptoms of many different mental health disorders that are frequently associated with functional disability, but it is not clear whether the same processes contribute to motivational impairments across disorders. This study focused on one possible factor, the willingness to exert cognitive effort, referred to as cognitive effort-cost decision making.

methodsWe examined performance on the deck choice task as a measure of cognitive effort-cost decision making, in which people choose to complete an easy task for a small monetary reward or a harder task for larger rewards, in 5 groups: healthy control (n = 80), schizophrenia/schizoaffective disorder (n = 50), bipolar disorder with psychosis (n = 58), current major depression (n = 60), and past major depression (n = 51). We examined cognitive effort-cost decision making in relation to clinician and self-reported motivation symptoms, working memory and cognitive control performance, and life function measured by ecological momentary assessment and passive sensing.

resultsWe found a significant diagnostic group × reward interaction (F

conclusionsThese findings suggest that the mechanisms contributing to motivational impairments differ among individuals with psychosis spectrum disorders versus depression.

Indexed as

Bipolar DisorderMajor Depressive DisorderSchizophreniaCognitionDecision MakingDepressionHumansMotivationRewardAnhedoniaDepressionEcological momentary assessmentEffortFunctionMotivationPsychosis

Identifiers

PMID37080416
PMCPMC10755814
OpenAlexW4366245705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.