Evidence map›Paper›PMID 37080202›Full record

ArticleCell reports2023

Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight.

Joseph K Bedree, Kristopher Kerns, Tsute Chen, Bruno P Lima, Guo Liu, Pin Ha, Jiayu Shi, Hsin Chuan Pan, Jong Kil Kim, Luan Tran and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
  2. Article
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  7. Biofilms: from the cradle of life to life support.NPJ biofilms and microbiomes · 2026
    Review
  8. Article
  9. Storage stability ofFrontiers in microbiology · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. Article
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  15. Article
  16. Article
  17. Review
  18. Spaceflight alters host-gut microbiota interactions.NPJ biofilms and microbiomes · 2024
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 8 institutions in 1 country.

Joseph K BedreeSection of Oral Biology, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, The Forsyth Institute, Cambridge, MA 02142, USA. Electronic address: jkbedree@ucla.edu.
Kristopher KernsDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA.
Tsute ChenDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142, USA; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Bruno P LimaDepartment of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Guo LiuSection of Oral Biology, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Pin HaSection of Orthodontics, Division of Growth & Development, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of Plastic and Reconstructive Surgery, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jiayu ShiSection of Oral Biology, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Hsin Chuan PanSection of Oral Biology, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jong Kil KimSection of Oral Biology, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Luan TranSection of Oral Biology, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Samuel S MinotMicrobiome Research Initiative, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Erik L HendricksonDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA.
Eleanor I LamontDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA.
Fabian SchulteForsyth Center for Salivary Diagnostics, Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA 02142, USA; Harvard School of Dental Medicine, Department of Developmental Biology, Boston, MA 02115, USA.
Markus HardtForsyth Center for Salivary Diagnostics, Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA 02142, USA; Harvard School of Dental Medicine, Department of Developmental Biology, Boston, MA 02115, USA.
Danielle StephensMultiplex Core, Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA 02142, USA.
Michele PatelMultiplex Core, Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA 02142, USA.
Alexis KokarasDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142, USA.
Louis StodieckBioServe Space Technologies, Department of Aerospace Engineering Sciences, University of Colorado, Boulder, CO 80303, USA.
Yasaman Shirazi-FardBone and Signaling Laboratory, Space Biosciences Division, NASA Ames Research Center, Mail Stop 288-2, Moffett Field, CA 94035, USA.
Benjamin WuDepartment of Bioengineering, School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jin Hee KwakSection of Orthodontics, Division of Growth & Development, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kang TingSection of Orthodontics, Division of Growth & Development, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chia SooDivision of Plastic and Reconstructive Surgery, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Orthopedic Surgery, School of Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jeffrey S McLeanDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195, USA.
Xuesong HeDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142, USA; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Wenyuan ShiDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142, USA. Electronic address: wshi@forsyth.org.
University of California, Los Angeles · USHarvard University · USUniversity of Washington · USAmes Research Center · USForsyth Technical Community College · USFred Hutch Cancer Center · USUniversity of Colorado Boulder · USUniversity of Minnesota · US

Funding

NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Dual roles of Nell-1 in craniofacial bones and brain through interaction with Cntnap4R01DE029353 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA, ZHANG, XINLI · 2020 to 2024
$2.5M
NELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2M
Wnt and PPARy Signaling in Nell-1 and BMP2 Mediated Bone RegenerationR01AR061399 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA · 2012 to 2016
$1.7M
Shedding Light on Microbial Dark MatterF31DE026057 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEDREE, JOSEPH KERNAN · 2016 to 2020
$156k
NCATS NIH HHS KL2 TR002317NIAMS NIH HHS R01 AR061399NIAMS NIH HHS R01 AR068835NIDCR NIH HHS F31 DE026057NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE029353
6 · The paper itself

Abstract

Understanding the axis of the human microbiome and physiological homeostasis is an essential task in managing deep-space-travel-associated health risks. The NASA-led Rodent Research 5 mission enabled an ancillary investigation of the gut microbiome, varying exposure to microgravity (flight) relative to ground controls in the context of previously shown bone mineral density (BMD) loss that was observed in these flight groups. We demonstrate elevated abundance of Lactobacillus murinus and Dorea sp. during microgravity exposure relative to ground control through whole-genome sequencing and 16S rRNA analyses. Specific functionally assigned gene clusters of L. murinus and Dorea sp. capable of producing metabolites, lactic acid, leucine/isoleucine, and glutathione are enriched. These metabolites are elevated in the microgravity-exposed host serum as shown by liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomic analysis. Along with BMD loss, ELISA reveals increases in osteocalcin and reductions in tartrate-resistant acid phosphatase 5b signifying additional loss of bone homeostasis in flight.

Indexed as

Gastrointestinal MicrobiomeSpace FlightChromatography, LiquidHumansRNA, Ribosomal, 16STandem Mass SpectrometryTravelRNA, Ribosomal, 16Sbone homeostasisCP: Metabolismgut-bone axisgut microbiomeInternational Space Station National Laboratorymicrogravityoral microbiomeRodent Research

Identifiers

PMID37080202
PMCPMC10344367
OpenAlexW4366442114

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.