Evidence map›Paper›PMID 37080165›Full record

ArticleNeuron2023

The DAXX tax: C9orf72 DNA repeat expansions drive gain- and loss-of-function pathology in c9FTD/ALS.

Feilin Liu, Wilfried Rossoll

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Feilin LiuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Wilfried RossollDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Electronic address: rossoll.wilfried@mayo.edu.
Mayo Clinic in Florida · US

Funding

Nuclear import receptors as modifiers of TDP-43 phase transition and toxicity in FTD/ALSR01AG077771 · NIA · MAYO CLINIC JACKSONVILLE · PI Wilfried Rossoll, James Shorter · 2023 to 2026
$2.8M
Capturing the molecular complexity of tau pathology-associated proteomes involved in the etiology of Alzheimer's disease and related dementiasRF1AG076122 · NIA · MAYO CLINIC JACKSONVILLE · PI ROSSOLL, WILFRIED · 2022 to 2023
$2.5M
Capturing the molecular complexity of tau pathology-associated proteomes involved in the etiology of Alzheimer's disease and related dementiasR01AG076122 · NIA · MAYO CLINIC JACKSONVILLE · PI Wilfried Rossoll · 2025 to 2026
$1.5M
Dissecting neuron-microglia-astrocyte interaction in AD pathogenesisR01AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2024 to 2024
$1.2M
NIA NIH HHS R01 AG068581NIA NIH HHS R01 AG076122NIA NIH HHS R01 AG077771NIA NIH HHS RF1 AG076122
6 · The paper itself

Abstract

In this issue of Neuron, Liu et al.

Indexed as

Amyotrophic Lateral SclerosisFrontotemporal DementiaC9orf72 ProteinCo-Repressor ProteinsDNA-Binding ProteinsDNA Repeat ExpansionEpigenesis, GeneticHumansMolecular ChaperonesC9orf72 ProteinC9orf72 protein, humanCo-Repressor ProteinsDAXX protein, humanDNA-Binding ProteinsMolecular Chaperones

Identifiers

PMID37080165
OpenAlexW4366439888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.