ArticleCell systems2023
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.
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Article in Cell systems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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Who cites it
6 citing papers in PubMed.
- MISSTE: a multiscale integrative spatial simulator for understanding the mechanisms underlying tissue ecosystems.bioRxiv : the preprint server for biology · 2026Article
- Challenges and opportunities for the next generation of computational tumor models.PLoS biology · 2025Article
- Systems Biology of the Cancer Cell.Annual review of biomedical engineering · 2025Review
- Linking spatial drug heterogeneity to microbial growth dynamics in theory and experiment.bioRxiv : the preprint server for biology · 2024Article
- Article
- A randomized controlled trial of a team science intervention to enhance collaboration readiness and behavior among early career scholars in the Clinical and Translational Science Award network.Journal of clinical and translational science · 2024Article
Corrections and comments
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Authors and funding
41 authors.
Frederick R AdlerDepartment of Mathematics, University of Utah, Salt Lake City, UT 84112, USA; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Alexander R A AndersonIntegrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Abhinav BhushanDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.
Paul BogdanMing Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Jose Javier Bravo-CorderoDivision of Hematology and Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Amy BrockDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
Yun ChenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Edna CukiermanCancer Signaling and Microenvironment Program, Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Kathleen E DelGiornoDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Gerald V DenisBoston University-Boston Medical Center Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
Meghan C Ferrall-FairbanksJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32611, USA.
Zev Jordan GartnerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; NSF Center for Cellular Construction, San Francisco, CA 94158, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Ronald N GermainLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Deborah M GordonDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Ginger HunterDepartment of Biology, Clarkson University, Potsdam, NY 13699, USA.
Mohit Kumar JollyCentre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, 560012, India.
Loukia Georgiou KaracostaDepartment of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Karthikeyan MythreyeDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Parag KatiraMechanical Engineering Department, San Diego State University, San Diego, CA 92182, USA; Computational Sciences Research Center, San Diego State University, San Diego, CA 92182, USA.
Rajan P KulkarniDepartment of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA; Department Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA; Department Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA; Operative Care Division, VA Portland Health Care System, Portland, OR 97239, USA.
Matthew L KutysDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Arthur D LanderDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Ashley M LaughneyInstitute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Herbert LevineCenter for Theoretical Biological Physics, Northeastern University, Boston, MA 02115, USA.
Emil LouMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Pedro R LowensteinDepartment of Neurosurgery, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109, USA.
Kristyn S MastersDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dana Pe'erComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Shelly R PeytonDepartment of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Emory University, Atlanta, GA 30322, USA.
Jeremy E PurvisDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gerald QuonDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.
Jennifer K RicherDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Cancer Center, Aurora, CO 80045, USA.
Nicole C RiddleDepartment of Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Analiz RodriguezDepartment of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Joshua C SnyderDepartment of Surgery, Duke University, Durham, NC 27710, USA; Department of Cell Biology, Duke University, Durham, NC 27710, USA.
Gregory Lee SzetoAllen Institute for Immunology, Seattle, WA 98109, USA; Seagen, Bothell, WA 98021, USA.
Claire J TomlinDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Itai YanaiPerlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Institute for Computational Medicine, NYU Langone Health, New York, NY 10016, USA.
Ioannis K ZervantonakisDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15232, USA; Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Hannah DueckDivision of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA. Electronic address: hannah.dueck@nih.gov.
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8MMultiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4MFunctional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4MImmunology Team Contributions to the PSIIMZIAAI000974 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$6.9MProbing cytosolic nucleic acid sensing pathways in cancerR01CA256188 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAUGHNEY, ASHLEY MARIE · 2021 to 2025
$3.5MUnderstanding breast cancer progression as a defect in the mechanics of tissue self-organizationU01CA244109 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN, GOGA, ANDREI · 2020 to 2024
$3.0MDissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystemR01CA280572 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOHN BLENIS, Ashley Marie Laughney · 2023 to 2026
$2.9MMultiscale analysis of metabolic inflammation as a driver of breast cancerU01CA243004 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DENIS, GERALD V, EMILI, ANDREW · 2020 to 2024
$2.8MMulti-cellular interactions defining the human brain metastatic nicheR01CA280414 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Benjamin Izar, Ashley Marie Laughney · 2023 to 2026
$2.8MRole of the collagen receptor LAIR-1 in glioma progression and the tumor immune microenvironmentR01NS127378 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pedro R. Lowenstein · 2022 to 2026
$1.8MNon-canonical Notch1 regulation of proliferation and adherens junctions in breast cancerR00CA226366 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KUTYS, MATTHEW L · 2020 to 2022
$667kRole of the smooth muscle layer in bladder cancer biology and progression: a systems and experimental approachR21CA266660 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAUGHNEY, ASHLEY MARIE, REAL, FRANCISCO XAVIER · 2022 to 2022
$374kIntramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA006927NCI NIH HHS R00 CA226366NCI NIH HHS R01 CA256188NCI NIH HHS R01 CA280414NCI NIH HHS R01 CA280572NCI NIH HHS R21 CA266660NCI NIH HHS U01 CA243004NCI NIH HHS U01 CA244109NINDS NIH HHS R01 NS127378
Abstract
Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.
Indexed as
Mass BehaviorNeoplasmsCommunicationHumans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.