ArticleScience (New York, N.Y.)2023
Syncytial nerve net in a ctenophore adds insights on the evolution of nervous systems.
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 101 citations in OpenAlex.
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- Lineage-specific elaboration of a conserved cnidogenic program drives cnidocyte diversification and illuminates cell type evolution.Research square · 2026Article
- The electrofluidic brain as a basement layer for neural computation.Communications biology · 2026Review
- An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission.bioRxiv : the preprint server for biology · 2026Article
- The 3D architecture of the ctenophore aboral organ and the evolution of complex integrative centers in animals.Science advances · 2026Article
- Neural connectome of the ctenophore statocyst.eLife · 2026Article
- The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution.Nature reviews. Neuroscience · 2026Review
- Article
- Hydra at the Crossroads of Evolution: Insights into Cell-type Diversification, Regeneration, and Epigenetic Regulation.Results and problems in cell differentiation · 2026Review
- The nascent RNA labelling compound 5-ethynyl uridine (EU) integrates into DNA in some animals.BMC molecular and cell biology · 2025Article
- Early transitions in the evolution of cognition.History and philosophy of the life sciences · 2025Article
- Neurite branching is associated with mixed microtubule polarity in sea anemone neurons.The Journal of experimental biology · 2025Article
- Beyond synapses: cytoplasmic connections in brain function and evolution.Biological reviews of the Cambridge Philosophical Society · 2025Review
- SynapseNet: Deep learning for automatic synapse reconstruction.Molecular biology of the cell · 2025Article
- Did axons evolve by activating cytokinesis during interphase? A hypothesis on the origin of neurons.Molecular biology of the cell · 2025Review
- An extinct clade of the basal Epitheliozoa: phylogenetic position and implication of the enigmatic Cambrian chancelloriids.Communications biology · 2025Article
- Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance.Cold Spring Harbor perspectives in biology · 2025Review
- The barn owl in systems and behavioral neuroscience: Progress and promise.Current opinion in neurobiology · 2025Review
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
A fundamental breakthrough in neurobiology has been the formulation of the neuron doctrine by Santiago Ramón y Cajal, which stated that the nervous system is composed of discrete cells. Electron microscopy later confirmed the doctrine and allowed the identification of synaptic connections. In this work, we used volume electron microscopy and three-dimensional reconstructions to characterize the nerve net of a ctenophore, a marine invertebrate that belongs to one of the earliest-branching animal lineages. We found that neurons in the subepithelial nerve net have a continuous plasma membrane that forms a syncytium. Our findings suggest fundamental differences of nerve net architectures between ctenophores and cnidarians or bilaterians and offer an alternative perspective on neural network organization and neurotransmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.