Evidence map›Paper›PMID 37079563›Full record

ArticlePloS one2023

Epicardial electrical heterogeneity after amiodarone treatment increases vulnerability to ventricular arrhythmias under therapeutic hypothermia.

Chin-Yu Lin, Ting-Yung Chang, Yu-Feng Hu, Yu-Cheng Hsieh, Yi-Jen Chen, Hung-I Yeh, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Tze-Fan Chao and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Chin-Yu LinDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0003-3282-7523
Ting-Yung ChangDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Yu-Feng HuDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0001-5715-2070
Yu-Cheng HsiehDepartment of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-Jen ChenDivision of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Hung-I YehDepartment of Medicine, Mackay Medical College, Taipei, Taiwan.
Yenn-Jiang LinDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Shih-Lin ChangDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Li-Wei LoDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Tze-Fan ChaoDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Fa-Po ChungDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Jo-Nan LiaoDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Ta-Chuan TuanDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Shih-Ann ChenDepartment of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
National Yang Ming Chiao Tung University · TWMackay Medical University · TWTaichung Veterans General Hospital · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmiodarone is commonly used during therapeutic hypothermia (TH) following cardiac arrest due to ventricular arrhythmias. However, electrophysiological changes and proarrhythmic risk after amiodarone treatment have not yet been explored in TH.

methodsEpicardial high-density bi-ventricular mapping was performed in pigs under baseline temperature (BT), TH (32-34°C), and amiodarone treatment during TH. The total activation time (TAT), conduction velocity (CV), local electrogram (LE) duration, and wavefront propagation from pre-specified segments were analyzed during sinus rhythm (SR) or right ventricular (RV) pacing (RVP), along with tissue expression of connexin 43. The vulnerability to ventricular arrhythmias was assessed.

resultsCompared to BT, TH increased the global TAT, decreased the CV, and generated heterogeneous electrical substrate during SR and RVP. During TH, the CV reduction and LE duration prolongation were greater in the anterior mid RV than in the other areas, which changed the wavefront propagation in all animals. Compared to TH alone, amiodarone treatment during TH further increased the TAT and LE duration and decreased the CV. Heterogeneous conduction was partially attenuated after amiodarone treatment. After TH and amiodarone treatment, the connexin 43 expression in the anterior mid RV was lower than that in the other areas, compatible with the heterogeneous CV reduction. The animals under TH and amiodarone treatment had a higher incidence of inducible ventricular arrhythmias than those under BT or TH without amiodarone.

conclusionElectrical heterogeneity during amiodarone treatment and TH was associated with vulnerability to ventricular arrhythmias.

Indexed as

AmiodaroneHypothermia, InducedAnimalsArrhythmias, CardiacConnexin 43Heart VentriclesSwineAmiodaroneConnexin 43

Identifiers

PMID37079563
PMCPMC10118167
OpenAlexW4366463705

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.