ArticlePLoS biology2023
Breaking spore dormancy in budding yeast transforms the cytoplasm and the solubility of the proteome.
Article in PLoS biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dry versus wet dormancy: suspended lives ofmSystems · 2026Review
- MFS-transporter Flr1 is a major drug-efflux transporter in Saccharomyces cerevisiae ascospores.FEMS yeast research · 2026Article
- Molecular and Biophysical Perspectives on Dormancy Breaking: Lessons from Yeast Spore.Biomolecules · 2025Review
- Characterization of RNA Helicase Genes inInternational journal of molecular sciences · 2025Article
- Killer meiotic drive executed by two alternative conformations of a single protein.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Polysome collapse and RNA condensation fluidize the cytoplasm.Molecular cell · 2024Article
- Microbial life in slow and stopped lanes.Trends in microbiology · 2024Review
- Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Chaperone regulation of biomolecular condensates.Frontiers in biophysics · 2024Article
- Compatible solutes determine the heat resistance of conidia.Fungal biology and biotechnology · 2023Article
- Fungal spore swelling and germination are restricted by the macrophage phagolysosome.Fungal biology · 2023Article
- The breaking of fungal spore dormancy: A coordinated transition.PLoS biology · 2023Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The biophysical properties of the cytoplasm are major determinants of key cellular processes and adaptation. Many yeasts produce dormant spores that can withstand extreme conditions. We show that spores of Saccharomyces cerevisiae exhibit extraordinary biophysical properties, including a highly viscous and acidic cytosol. These conditions alter the solubility of more than 100 proteins such as metabolic enzymes that become more soluble as spores transit to active cell proliferation upon nutrient repletion. A key regulator of this transition is the heat shock protein, Hsp42, which shows transient solubilization and phosphorylation, and is essential for the transformation of the cytoplasm during germination. Germinating spores therefore return to growth through the dissolution of protein assemblies, orchestrated in part by Hsp42 activity. The modulation of spores' molecular properties are likely key adaptive features of their exceptional survival capacities.
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