Evidence map›Paper›PMID 37079400›Full record

ArticleIUCrJ2023

Structural analysis of the Toll-like receptor 15 TIR domain.

Kyung Yeol Ko, Wan Seok Song, Jeongho Park, Geun Shik Lee, Sung Il Yoon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Immunoinformatics-Aided Design of a Multiepitope Vaccine AgainstBioinformatics and biology insights · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kyung Yeol KoDivision of Biomedical Convergence, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Wan Seok SongInstitute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea.ORCID 0000-0002-8104-8027
Jeongho ParkCollege of Veterinary Medicine, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Geun Shik LeeCollege of Veterinary Medicine, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Sung Il YoonDivision of Biomedical Convergence, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Kangwon National University · KR

Funding

National Research Foundation of Korea 2019R1A2C1002100National Research Foundation of Korea RS-2023-00208153
6 · The paper itself

Abstract

Toll-like receptors (TLRs) activate innate immunity in response to pathogen-associated molecular patterns (PAMPs). The ectodomain of a TLR directly senses a PAMP and the intracellular TIR domain dimerizes to initiate a signaling cascade. The TIR domains of TLR6 and TLR10, which belong to the TLR1 subfamily, have been structurally characterized in a dimer, whereas those of other subfamilies, including TLR15, have not been explored at the structural or molecular level. TLR15 is a TLR unique to birds and reptiles that responds to virulence-associated fungal and bacterial proteases. To reveal how the TLR15 TIR domain (TLR15

Indexed as

Toll-Like Receptor 1Toll-Like ReceptorsModels, MolecularProtein Structure, TertiarySignal TransductionToll-Like Receptor 1Toll-Like Receptorsdimersmolecular recognitionprotein structureTIR domainsTLR15Toll-like receptorsX-ray crystallography

Identifiers

PMID37079400
PMCPMC10161769
OpenAlexW4366463514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.