ArticleGeroScience2023
Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.
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Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
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Who cites it
48 citing papers in PubMed, 58 citations in OpenAlex.
- Senescent Cell Heterogeneity: Tissue-Dependent Signatures and Age Dynamics Revealed by Human scRNA-Seq Data.International journal of molecular sciences · 2026Article
- Senotypes define the diverse landscape of senescent cells.Nature aging · 2026Review
- Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice.Nature aging · 2026Article
- The aging extracellular matrix as a missing link in senescent cell accumulation and persistence.Nature aging · 2026Article
- Cellular hallmarks and aging clock of the human lung parenchyma.Nature communications · 2026Article
- SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types.Molecular cell · 2026Article
- Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter.Nature aging · 2026Article
- Artificial intelligence for design strategies of tissue engineering materials.Fundamental research · 2026Review
- FAK modulates immune response and fibroblast activation in biomaterial-induced fibrosis.Biomaterials · 2026Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Senolytic Changes in Murine Arteriovenous Fistulas with CKD.Kidney360 · 2026Article
- Immune Roles of Canonically Non-Immune Cells in Biomaterials Response.Cell biomaterials · 2026Article
- Towards a context-aware framework for cellular senescence.Biogerontology · 2026Review
- Overview of molecular signatures of senescence and associated resources: pros and cons.FEBS open bio · 2026Review
- γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.Nature communications · 2026Article
- Cellular senescence in human liver under normal aging and cancer.Cell genomics · 2026Article
- ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement.Genome biology · 2026Article
- SenCat: Cataloging human cell senescence through multiomic profiling of multiple senescent primary cell types.bioRxiv : the preprint server for biology · 2026Article
- SAKURA: a knowledge-guided approach to recovering important, rare signals from single-cell data.Genome biology · 2026Article
- From Cerebrovascular Injury to Vascular Cognitive Impairment and Dementia: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles.Biomedicines · 2026Review
Corrections and comments
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Authors and funding
26 authors at 8 institutions in 2 countries.
Christopher CherryTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James I AndorkoTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kavita KrishnanTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joscelyn C MejíasTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Helen Hieu NguyenTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Katlin B StiversTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elise F Gray-GaillardTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anna RutaTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jin HanTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Naomi HamadaDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Masakazu HamadaDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Ines SturmlechnerDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Shawn TrewarthaDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
John H MichelTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Locke Davenport HuyerTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Matthew T WolfLaboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Ada J TamDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexis N PeñaTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shilpa KeerthivasanTumor Microenvironment Thematic Research Center, Bristol Myers Squibb, San Francisco, CA, USA.
Claude Jordan Le SauxDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Elana J FertigDepartment of Biomedical Engineering and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Darren J BakerDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Franck HousseauBloomberg~Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jan M van DeursenDepartment of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Drew M PardollBloomberg~Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jhe@jhu.edu.ORCID 0000-0002-5066-1996
Johns Hopkins University · USBloomberg (United States) · USMayo Clinic in Florida · USMayo Clinic in Arizona · USBristol-Myers Squibb (United States) · USNational Cancer Institute · USUniversity Medical Center Groningen · NLUniversity of California, San Francisco · US
Funding
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MCancer Biomaterials EngineeringZIABC012021 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOLF, MATTHEW · 2020 to 2025
$6.7MJHU-Mayo-NIA Murine Senescence Mapping Program (JMN-MSMP)U54AG079779 · NIA · JOHNS HOPKINS UNIVERSITY · PI JENNIFER H ELISSEEFF · 2022 to 2026
$6.4MBiomaterials-directed regenerative immunotherapiesDP1AR076959 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2019 to 2023
$5.7MTranslational Aging Research Training ProgramT32AG058527 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir, Esther Seunghee Oh · 2018 to 2026
$4.0MT32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5MCellular senescence in aging and age-related disease (Supplement application)R01AG057493 · NIA · MAYO CLINIC ROCHESTER · PI BRAM, RICHARD J · 2018 to 2022
$1.9MSingle-cell and imaging data integration software to spatially resolve the tumor microenvironmentU01CA253403 · NCI · JOHNS HOPKINS UNIVERSITY · PI FERTIG, ELANA · 2020 to 2022
$1.2MNCI NIH HHS T32 CA153952NCI NIH HHS U01 CA253403NCI NIH HHS U01CA253403NIAMS NIH HHS DP1 AR076959NIA NIH HHS R01 AG057493NIA NIH HHS T32 AG058527NIA NIH HHS U54 AG079779NIGMS NIH HHS T32 GM136577
Abstract
Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells' (SnCs) pathological role and therapeutic interest, their phenotype in vivo remains poorly defined. Here, we developed an in vivo-derived senescence signature (SenSig) using a foreign body response-driven fibrosis model in a p16-CreER
Indexed as
AgingCellular SenescenceAnimalsFibroblastsHumansMachine LearningMicePhenotypeFibrosisRNA sequencingSenescence
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.