ArticleEJNMMI physics2023
Quantitative application of dual-phase 99mTc-sestamibi SPECT/CT imaging of parathyroid lesions: identification of optimal timing in secondary hyperparathyroidism.
Article in EJNMMI physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 7 citations in OpenAlex.
- Quantitative and comparative assessment of Tc-99 m MIBI imaging in parathyroid adenomas: associations with biochemical, morphological, and histopathological.Annals of nuclear medicine · 2026Article
- Article
- Challenges and unmet needs of [European journal of nuclear medicine and molecular imaging · 2026Article
- MR Pulse Sequences for Parathyroid Adenoma Imaging Using [Nuclear medicine and molecular imaging · 2026Article
- A novel missense variant in the calcium-sensing receptor gene in a dog with hypercalcemia.Journal of veterinary internal medicine · 2026Article
- Differences in quantitative 99mTc-MIBI SPECT/CT parameters between parathyroid adenoma and hyperplasia in secondary hyperparathyroidism.Frontiers in endocrinology · 2026Article
- Parathyroidectomy for secondary hyperparathyroidism in chronic kidney disease: a retrospective study of predictors of persistence and postoperative outcomes.BMC nephrology · 2025Article
- Surgical Management of Mediastinal Ectopic Parathyroids.Journal of personalized medicine · 2025Review
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeIn this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background ratio (TBR) of parathyroid lesions to thyroid tissue in early-phase single-photon emission computed tomography/computed tomography (SPECT/CT) versus delayed-phase SPECT/CT in patients with secondary hyperparathyroidism (SHPT) in order to determine the optimal timing of 99mTc- methoxyisobutylisonitrile (99mTc-MIBI) SPECT/CT imaging.
methodsSeventeen patients with a history of chronic kidney failure stage 5 on hemodialysis, underwent pre-operative parathyroid scintigraphy for detection and localization of parathyroid lesions. Retrospective analysis was conducted for lesions with focal accumulation of 99mTc-MIBI. All patients underwent dual-phase 99mTc-MIBI parathyroid scintigraphy and dual-phase SPECT/CT. SUVmax of parathyroid lesions and thyroid tissues was measured.
resultsMean SUVmax of parathyroid lesions was 4.86 on early-phase and 2.58 on delayed-phase SPECT/CT, respectively. Mean TBR was 1.14 on early phase and 1.48 on delayed-phase SPECT/CT, respectively. Statistically significant differences in SUVmax and TBR between dual-phase SPECT/CT were observed (P < 0.001).
conclusionsDelayed-phase SPECT/CT in SHPT is required because of the better image contrast.
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