ArticleJournal of autism and developmental disorders2024
An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure.
Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Multimodal imaging reveals resilient memory networks in carriers of pathogenic ARID1B variants.Translational psychiatry · 2026Article
- Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes.Autism research : official journal of the International Society for Autism Research · 2025Review
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project.Translational psychiatry · 2025Article
- Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model.Frontiers in neuroinformatics · 2025Article
- Alterations in the white matter fiber tracts of preschool-aged children with autism spectrum disorder: an automated fiber quantification study.Quantitative imaging in medicine and surgery · 2024Article
- White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis.Translational psychiatry · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fixel-based analysis was used to probe age-related changes in white matter micro- and macrostructure of the corpus callosum between participants with (N = 54) and without (N = 50) autism spectrum disorder (ASD). Data were obtained from the Autism Brain Imaging Data Exchange-II (ABIDE-II). Compared to age-matched controls, young adolescents with ASD (11.19 ± 7.54 years) showed reduced macroscopic fiber cross-section (logFC) and combined fiber-density and cross-section (FDC). Reduced fiber-density (FD) and FDC was noted in a marginally older (13.87 ± 3.15 years) ASD cohort. Among the oldest ASD cohort (17.07 ± 3.56 years), a non-significant trend indicative of reduced FD was noted. White matter aberration appears greatest and most widespread among younger ASD cohorts. This supports the suggestion that some early neuropathophysiological indicators in ASD may dissipate with age.
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Registered trials
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