ArticleClinical oral investigations2023
Effect of leukocyte-platelet-rich fibrin (L-PRF) on the rate of orthodontic tooth movement and expression of various biomarkers in gingival crevicular fluid.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The efficacy and safety of corticotomy and periodontally accelerated osteogenic orthodontic interventions in tooth movement: an updated meta-analysis.Head & face medicine · 2024Pooled it
- Impact of periodontal microRNAs associated with alveolar bone remodeling during orthodontic tooth movement: a randomized clinical trial.Journal of translational medicine · 2024Trial
- Effect of 3D-printing assisted micro-osteoperforations on the rate of canine retraction: a clinical investigation.BMC oral health · 2025Article
- Acceleration of Orthodontic Tooth Movement: A Bibliometric and Visual Analysis.International dental journal · 2025Article
- Comparison of two micro-osteoperforation protocols using mini-screws on the rate and type of extraction space closure: A randomized clinical trial.Dental research journal · 2025Article
- Review
- Effect of sequential Injectable Platelet Rich Fibrin (i-PRF) following Leukocyte-Platelet Rich Fibrin (L-PRF) on maxillary canine retraction: split-mouth randomized controlled trial.Journal of oral biology and craniofacial researchArticle
- Efficacy of leukocyte-platelet rich fibrin (L-PRF) plug in accelerating the maxillary canine retraction in young adults: A split mouth randomized controlled trial.Journal of oral biology and craniofacial researchArticle
- Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo assess the outcome of leukocyte-platelet-rich fibrin (L-PRF) on the rate of maxillary canine retraction and its correlation with the levels of Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and RANKL:OPG in the gingival crevicular fluid (GCF) during comprehensive orthodontic treatment. SUBJECTS AND
methodsEighteen females who required all 1st premolars extraction for the correction of their class I bimaxillary protrusion malocclusions were included. The L-PRF plugs were placed in the experimental side 1st premolar extraction sockets. Canine retraction was performed by sliding mechanics. Canine retraction was assessed from the maxillary study models prepared just before the extraction (T
resultsIn experimental sides, the amount of canine retraction was statistically more during the T
conclusionsThe L-PRF accelerated the rate of maxillary canine retraction by 0.28 mm over an 8-week period. The L-PRF favored the local osteoclastogenesis by enhancing the RANKL and suppressing the OPG concentrations. There was no significant correlation between the rate of maxillary canine retraction and expression of RANKL, OPG, and RANKL:OPG in GCF.
trial registrationThe Clinical Trials Registry of India (Reg. No. CTRI/2020/10/028390, Date-13.10.2020).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.