Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023
Oral health-related quality of life after radiation therapy for head and neck cancer: the OraRad study.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02057510 (Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients
Who cites it
20 citing papers in PubMed, 18 citations in OpenAlex.
- Photobiomodulation for restoring salivary flow after radiotherapy in head and neck cancer: a randomised placebo-controlled trial.BMC oral health · 2025Trial
- Reliability of the electronic patient reported outcome measures for assessing xerostomia, dysphagia and quality of life in Spanish patients with head and neck cancer: a randomised crossover design.Health and quality of life outcomes · 2025Trial
- Integrating submandibular gland transfer with proton therapy to preserve salivary function.Clinical and translational radiation oncology · 2026Article
- Implementation of the "l'O à la bouche" Therapeutic Patient Education Program at a French Cancer Center: A Multidisciplinary Approach for Managing Post-Cancer Oral Toxicities.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Radiotherapy-Associated Pain in Head and Neck Cancer: From Clinical Burden to Neuroimmune Modulator.Journal of clinical medicine · 2026Review
- Unmet supportive care needs among head and neck cancer survivors in China: multicenter cross-sectional study.Frontiers in public health · 2026Article
- Oral health-related quality of life in head and neck cancer survivors in Egypt within the first year after radiotherapy: a multivariable analysis.BMC oral health · 2025Article
- The impact of medications on salivary flow and oral health-related quality of life in postradiation head and neck cancer patients: results of the OraRad study.Oral surgery, oral medicine, oral pathology and oral radiology · 2025Article
- Oral health-related quality of life among long-term head and neck cancer survivors: a multinational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Chronic Oral Complications of Oral Cancer Therapy.Dental clinics of North America · 2025Review
- Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.Oral diseases · 2025Observational
- Oral health-related quality of life in head and neck cancer: a systematic review.Frontiers in oral health · 2025Review
- Oral health-related quality of life in Tunisian patients following radiotherapy for head and neck tumors: a cross-sectional study.The Pan African medical journal · 2025Observational
- Cross-cultural adaptation, reliability, and validity of a Chinese version of the swallowing impairment score.Frontiers in psychology · 2025Article
- Current basic and preclinical research for treatment of radiation therapy-induced hyposalivation.JADA foundational science · 2025Article
- Response of Spontaneous Oral Tumors in Canine Cancer Patients Treated with Stereotactic Body Radiation Therapy (SBRT).Radiation research · 2024Article
- Pre- and Post-Operative Quality of Life in Patients with Osteoradionecrosis of the Jaw.Cancers · 2024Article
- Unravelling Quality of Life for Head and Neck Cancer Patients after VMAT Radiation Therapy: Insights from Toxicity, Dosimetry and Symptoms Correlation.Clinics and practice · 2024Article
- Exploring predictors of dysphagia in survivors of head and neck cancer: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Longitudinal Trends in Health-related Quality of Life among Radiotherapy Patients: A Short-term Result of Prospective EORTC QLQ- C30-based Study.Journal of medical physicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 1 country.
Funding
Abstract
purposeHead and neck cancer (HNC) treatment results in morbidity impacting quality of life (QOL) in survivorship. This analysis evaluated changes in oral health-related QOL (OH-QOL) up to 2 years after curative intent radiation therapy (RT) for HNC patients and factors associated with these changes.
methods572 HNC patients participated in a multicenter, prospective observational study (OraRad). Data collected included sociodemographic, tumor, and treatment variables. Ten single-item questions and 2 composite scales of swallowing problems and senses problems (taste and smell) from a standard QOL instrument were assessed before RT and at 6-month intervals after RT.
resultsThe most persistently impacted OH-QOL variables at 24 months included: dry mouth; sticky saliva, and senses problems. These measures were most elevated at the 6-month visit. Aspects of swallowing were most impacted by oropharyngeal tumor site, chemotherapy, and non-Hispanic ethnicity. Problems with senses and dry mouth were worse with older age. Dry mouth and sticky saliva increased more among men and those with oropharyngeal cancer, nodal involvement, and use of chemotherapy. Problems with mouth opening were increased by chemotherapy and were more common among non-White and Hispanic individuals. A 1000 cGy increase in RT dose was associated with a clinically meaningful change in difficulty swallowing solid food, dry mouth, sticky saliva, sense of taste, and senses problems.
conclusionsDemographic, tumor, and treatment variables impacted OH-QOL for HNC patients up to 2 years after RT. Dry mouth is the most intense and sustained toxicity of RT that negatively impacts OH-QOL of HNC survivors. CLINICALTRIALS: GOV IDENTIFIER: NCT02057510; first posted February 7, 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.